Evidence map›Paper›PMID 42635699›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid-Beta Pathology in Alzheimer's Mice.

Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Fengjuan WuBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.ORCID https://orcid.org/0000-0001-9936-4004
Jihua FanBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.
Xiang ZhouBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.
Zhiqi YangBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.
Mingyue GongBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.
Mingzhu HuangBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.
Zhenlu CaiBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.
Shaofan YangBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.
Teng TengBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.
Chuanyan YangBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.
Jin LiBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.
Haoyu WangBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.
Shuangshuang DaiDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, Army Medical University, Chongqing, China.ORCID https://orcid.org/0000-0001-8386-0126
Chunhai ChenDepartment of Occupational Health, Third Military Medical University, Chongqing, China.
Xiaowei ChenBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.
Manxia WangDepartment of Neurology, Lanzhou University Second Hospital, Lanzhou, China.
Kuan ZhangBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.ORCID https://orcid.org/0000-0003-0701-0570

Funding

National Natural Science Foundation of China 82371485National Natural Science Foundation of China 82588301Natural Science Foundation of Chongqing CSTB2024NSCQ-JQX0024
6 · The paper itself

Abstract

Astrocytes in the medial entorhinal cortex (MEC) regulate spatial exploration, yet their functional impairment in Alzheimer's disease (AD) remains poorly understood. Here, we show that fragmented spatial exploration in APP/PS1 mice correlates with diminished exploration-evoked Ca

Indexed as

Alzheimer’s diseaseAQP4astrocyteglial progenitor cellmedial entorhinal cortexneuroinflammationspatial exploration

Identifiers

PMID42635699
PMCPMC13502269

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.