Evidence map›Paper›PMID 42635873›Full record

ArticleJournal of cardiovascular translational research2026

Metabolic Signatures of Atrial Functional Impairment in Paroxysmal Atrial Fibrillation Patients: A CMR Strain-metabolomics Study.

Tianyi Shi, Bin Liu, Xiaoyu Lian, Chao Peng, Yanjing Wang, Wendi Shi, Heyuan Chen, Sihui He, Huan Sun

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In one paragraph

Article in Journal of cardiovascular translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tianyi Shi *Department of Cardiology, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Erdao District, Changchun, Jilin, 130033, China.
Bin Liu *Department of Cardiology, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Erdao District, Changchun, Jilin, 130033, China.
Xiaoyu LianDepartment of Cardiology, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Erdao District, Changchun, Jilin, 130033, China.
Chao PengDepartment of Cardiology, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Erdao District, Changchun, Jilin, 130033, China.
Yanjing WangRadiology of Cardiology, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Erdao District, Changchun, Jilin, 130033, China.
Wendi ShiChina-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Erdao District, Changchun, Jilin, 130033, China.
Heyuan ChenChina-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Erdao District, Changchun, Jilin, 130033, China.
Sihui HeThe Second Hospital of Jilin University, No. 218 Ziqiang Street, Nanguan District, Changchun, Jilin, 130041, China.
Huan SunDepartment of Cardiology, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Erdao District, Changchun, Jilin, 130033, China. sunhuan0404@jlu.edu.cn.ORCID 0000-0002-8283-8143

Funding

Jilin Provincial Department of Science and Technology YDZJ202501ZYTS071
6 · The paper itself

Abstract

Atrial fibrillation (AF) is the most common clinical arrhythmia. Patients with paroxysmal atrial fibrillation (PAF) may exhibit reversible changes in atrial function at an early stage. Identifying biomarkers for this stage is crucial for delaying disease progression. This study integrated cardiac magnetic resonance (CMR) atrial strain analysis with untargeted metabolomics. Despite similar left atrial sizes, significant differences in atrial strain were observed among PAF patients. Seven differential metabolites-phosphatidylcholine, inosine, bilirubin, biliverdin, 3-methylhistidine, L-tryptophan, and pantothenic acid-were identified as potential biomarkers associated with declining atrial function. These findings suggest that peripheral blood metabolites are associated with atrial functional impairment in PAF patients. However, these exploratory findings warrant further investigation in larger prospective cohorts.

Indexed as

Atrial FibrillationAtrial Function, LeftEnergy MetabolismMagnetic Resonance Imaging, CineMetabolomicsAgedBiomarkersFemaleHumansMaleMiddle AgedPredictive Value of TestsBiomarkersAtrial StrainCardiac Magnetic ResonanceMetabolomicsParoxysmal Atrial Fibrillation

Identifiers

PMID42635873

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.