ArticleGeroScience2026
Bridging structure and function: triple network remodeling driven by white matter hyperintensities in vascular cognitive impairment.
Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
Funding
Abstract
Cerebral small vessel disease-induced vascular cognitive impairment (VCI) is a major contributor to the pathogenesis of dementia. Accumulating evidence suggests that VCI disrupts large-scale brain networks, but how it selectively impairs inter-network connectivity and contributes to specific cognitive deficits remains unclear. This case-control study included 132 participants (74 VCI patients, 58 healthy controls) who underwent neuropsychological assessments and multimodal MRI. To investigate changes in core networks supporting higher-order cognition, we analyzed intra- and inter-network functional connectivity of the default mode network (DMN), salience network (SN), and frontoparietal network (FPN) using independent component analysis (ICA) and dynamic functional network connectivity (dFNC). Structural alterations were assessed using voxel-based morphometry and tract-based spatial statistics. Mediation analysis evaluated whether white matter hyperintensities (WMH) affected cognition through altered network connectivity. VCI participants showed gray matter atrophy within cognitive networks, including the hippocampus, orbitofrontal cortex, and middle frontal gyrus. White matter integrity was also compromised, with reduced fractional anisotropy in the SN and FPN. Functional connectivity analysis revealed decreased intra-network connectivity in the precuneus (DMN), supramarginal gyrus (SN), and inferior parietal lobule (FPN). dFNC analysis indicated less time spent in a state of strong left FPN-SN connectivity. Mediation analysis revealed a hierarchical pattern of network interactions. SN connectivity partially mediated the relationship between the DMN and FPN, while DMN-right FPN connectivity fully mediated the association between WMH burden and memory impairment. This study shows that VCI involves structural and functional network disruption. Inter-network dysfunction links vascular burden to memory impairment. These findings may inform early detection and network-based interventions for vascular cognitive impairment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.