ReviewJournal of endocrinological investigation2026
Sleep deprivation as a modulator of thyroid function: a systematic review and meta-analysis.
Review in Journal of endocrinological investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSleep deprivation is prevalent worldwide and is associated with multiple endocrine disturbances. Although several studies have explored the relationship between sleep deprivation and thyroid parameters, no review has synthesized existing evidence. METHODOLOGY: A systematic search of PubMed, Cochrane CENTRAL, Web of Science, and Scopus was conducted for studies published through November 2025 examining the effects of total or partial sleep deprivation on thyroid function. Studies with extractable quantitative data were considered for meta-analysis, while others were narratively synthesized per SWiM guidelines. Primary outcomes included thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4), with effect sizes calculated using Hedges' g.
resultsTwenty-five studies met the inclusion criteria, including eight in the meta-analysis and seventeen in the narrative synthesis. Sleep deprivation was associated with a significant increase in TSH (Hedges' g = 1.49, 95% CI 0.17-2.81, p = 0.027) and fT3 (Hedges' g = 3.82, 95% CI 1.71-5.94, p < 0.001). Although fT4 levels increased, the pooled effect was not statistically significant (Hedges' g = 0.48, 95% CI 0.36-1.33, p = 0.264). TT3, TT4, and rT3 also showed no significant changes. Narrative findings were mostly consistent, with most reporting elevated TSH, while fT3 and fT4 findings were more variable. Prolonged sleep restriction studies exhibited less consistency, suggesting possible adaptation of the hypothalamic-pituitary-thyroid axis over time.
conclusionSleep deprivation is associated with alterations in TSH and fT3, highlighting the sensitivity of the hypothalamic-pituitary-thyroid axis to insufficient sleep and emphasizing the importance of sleep history when interpreting thyroid function tests.
Indexed as
Identifiers
42635905What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.