Evidence map›Paper›PMID 42635920›Full record

ReviewProbiotics and antimicrobial proteins2026

Postbiotic-Based Regenerative Therapy for Intrauterine Adhesions: Mechanisms, Microbiota Crosstalk, and Translational Perspectives.

Hui Li, Ziqin Li, Zhaoqi Liu, Ding Wang, Yongqin Zhou

Abstract readReview
PubMed Publisher
In one paragraph

Review in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hui Li *Department of Gynaecology and Obstetrics, School of Maternity and Children's Clinical Medicine, China Three Gorges University, Yichang, 443002, China.
Ziqin Li *Department of Gynaecology and Obstetrics, Wuchang Hospital, Wuhan, 43000, China.
Zhaoqi LiuHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443002, China.
Ding WangDepartment of Gynaecology and Obstetrics, School of Maternity and Children's Clinical Medicine, China Three Gorges University, Yichang, 443002, China. 30271711@qq.com.
Yongqin ZhouHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443002, China. 3842690284@qq.com.

Funding

Natural Science Foundation of Yichang Municipality A24-2-058Natural Science Foundation of Yichang Municipality A25-2-038
6 · The paper itself

Abstract

Intrauterine adhesions (IUA) correlate with reproductive tract dysbiosis, including reduced Lactobacillus, overgrowth of Gardnerella, Prevotella, and Klebsiella, and fungal imbalance involving Candida albicans. These changes promote endometrial fibrosis through TGF-β/Smad activation, TLR4/NF-κB-driven inflammation, and ferroptosis. Postbiotics, probiotic-derived metabolites, suppress fibrotic signaling, modulate immunity, and restore microbial balance. This review synthesizes current evidence on microbiota-IUA interplay and promising postbiotic-based therapies, highlighting translational platforms such as hydrogel delivery systems and multi-omics integration.

Indexed as

DysbiosisEndometrial fibrosisIntrauterine adhesionsMicrobiotaPostbiotics

Identifiers

PMID42635920

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.