Evidence map›Paper›PMID 42635977›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A.

Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng and 6 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jiankun LiuAging and Vascular Diseases, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Aging and Diseases, Nanchang, China.ORCID https://orcid.org/0009-0006-6527-8945
Hongfei LiuVascular Function Laboratory, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Human Aging, Nanchang, China.ORCID https://orcid.org/0000-0003-4335-0652
Yiqi WanAging and Vascular Diseases, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Aging and Diseases, Nanchang, China.
Andong WuAging and Vascular Diseases, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Aging and Diseases, Nanchang, China.
Jiayu QiuAging and Vascular Diseases, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Aging and Diseases, Nanchang, China.
Xueting GongAging and Vascular Diseases, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Aging and Diseases, Nanchang, China.ORCID https://orcid.org/0000-0002-1197-3452
Ya ZhaoAging and Vascular Diseases, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Aging and Diseases, Nanchang, China.ORCID https://orcid.org/0009-0008-6971-0402
Yuanyuan LiAging and Vascular Diseases, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Aging and Diseases, Nanchang, China.
Bingbing ZhouAging and Vascular Diseases, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Aging and Diseases, Nanchang, China.
Yangyi ZhengAging and Vascular Diseases, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Aging and Diseases, Nanchang, China.
Fang WuAging and Vascular Diseases, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Aging and Diseases, Nanchang, China.
Yuanzheng ZhuAging and Vascular Diseases, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Aging and Diseases, Nanchang, China.
Weixin LvAging and Vascular Diseases, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Aging and Diseases, Nanchang, China.ORCID https://orcid.org/0009-0009-8620-9932
Xueer LiAging and Vascular Diseases, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Aging and Diseases, Nanchang, China.ORCID https://orcid.org/0009-0005-8882-6169
Qiang YuanAging and Vascular Diseases, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Aging and Diseases, Nanchang, China.
Xiao-Li TianAging and Vascular Diseases, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Aging and Diseases, Nanchang, China.ORCID https://orcid.org/0000-0002-0868-7025

Funding

Jiangxi Province Key Laboratory of Aging and Disease 2024SSY07161Key Program of the National Natural Science Foundation of China 82330046
6 · The paper itself

Abstract

Our previous genome-wide screening has linked THSD7A (thrombospondin type 1 domain containing 7A) gene to human coronary artery disease (CAD). How THSD7A contributes to atherosclerosis, however, remains unclear. In this study, we show THSD7A is increased in human carotid arteries and mouse atherosclerotic plaques. In apolipoprotein E knockout (ApoE

Indexed as

atherosclerosisCESBPDendothelial inflammationTHSD7Aαvβ3

Identifiers

PMID42635977
PMCPMC13502345

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.