Evidence map›Paper›PMID 42636034›Full record

Trial reportJournal of comparative effectiveness research2026

Indirect treatment comparisons find enhanced effectiveness of pegcetacoplan versus crovalimab in both complement inhibitor-naïve and -experienced patients with paroxysmal nocturnal hemoglobinuria.

Raymond Siu Ming Wong, Koo Wilson, Zalmai Hakimi, Mikolaj Parkitny, Piotr Wojciechowski, Catherine Flynn, Francis Fatoye

Abstract readClinical Trial, Phase IIIComparative StudyRandomized Controlled Trial
In one paragraph

Trial report in Journal of comparative effectiveness research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Raymond Siu Ming WongSir Y.K. Pao for Cancer & Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong.ORCID 0000-0002-9011-4268
Koo WilsonSwedish Orphan Biovitrum AB (Sobi), Stokholm, Sweden.ORCID 0000-0002-8732-8249
Zalmai HakimiSwedish Orphan Biovitrum AB (Sobi), Stokholm, Sweden.ORCID 0000-0001-5835-8599
Mikolaj ParkitnyClever-Access, Krakow, PolandPiotr Wojciechowski.ORCID 0009-0007-8652-6749
Piotr WojciechowskiClever-Access, Krakow, PolandPiotr Wojciechowski.ORCID 0000-0001-8400-1171
Catherine FlynnSt James's Hospital, Dublin, Ireland.ORCID 0000-0002-9740-6757
Francis FatoyeManchester Metropolitan University, Manchester, UK.ORCID 0000-0002-3502-3953

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antibodies, Monoclonal, HumanizedComplement Inactivating AgentsHemoglobinuria, ParoxysmalPolyethylene GlycolsAdultAgedFemaleHumansMaleMiddle AgedPeptides, CyclicTreatment OutcomeAntibodies, Monoclonal, HumanizedComplement Inactivating AgentsCrovalimabeculizumabpegcetacoplanPeptides, CyclicPolyethylene Glycolscrovalimabindirect treatment comparisonparoxysmal nocturnal hemoglobinuriapegcetacoplan

Identifiers

PMID42636034
PMCPMC13648046

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.