Evidence map›Paper›PMID 42637889›Full record

ArticleNature microbiology2026

Candida auris uses nutrient sensing to modulate virulence and host immune responses.

Irma Tedja, Harshini Weerasinghe, Garrett Bryak, Helen Stölting, Tricia L Lo, Claudia Simm, Angavai Swaminathan, Calvin A Kraupner-Taylor, Paul F Harrison, Françios A B Olivier and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Diabetes and Immunosuppression Drive Distinct Patterns ofbioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Irma TedjaDepartment of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0003-0055-0208
Harshini WeerasingheDepartment of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Garrett BryakDepartment of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.
Helen StöltingDepartment of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0002-7830-2776
Tricia L LoDepartment of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Claudia SimmDepartment of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Angavai SwaminathanDepartment of Biochemistry and Molecular Biology and the Development and Stem Cells Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Calvin A Kraupner-TaylorDepartment of Biochemistry and Molecular Biology and the Development and Stem Cells Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Paul F HarrisonGenomics and Bioinformatics Platform, Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0002-3980-268X
Françios A B OlivierDepartment of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0002-0725-1000
Michael J McDonaldSchool of Biological Sciences, Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0002-5735-960X
Shankar ThangamaniDepartment of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA. sthangam@purdue.edu.ORCID http://orcid.org/0000-0002-0031-2392
Traude H BeilharzDepartment of Biochemistry and Molecular Biology and the Development and Stem Cells Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia. traude.beilharz@monash.edu.ORCID http://orcid.org/0000-0002-8942-9502
Ana TravenDepartment of Biochemistry and Molecular Biology and the Infection Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia. ana.traven@monash.edu.ORCID http://orcid.org/0000-0001-6252-3104

Funding

Mechanisms of Candida auris Colonization in the SkinR01AI177604 · NIAID · PURDUE UNIVERSITY · PI Shankar Thangamani · 2023 to 2026
$2.4M
Department of Education and Training | Australian Research Council (ARC) CE230100001Department of Health | National Health and Medical Research Council (NHMRC) APP2002520, 2033452NIAID NIH HHS R01 AI177604U.S. Department of Health & Human Services | National Institutes of Health (NIH) 1R01AI177604
6 · The paper itself

Abstract

The emergence of Candida auris as a pathogen required host adaptation and evasion of mammalian immunity, but the mechanisms are poorly understood. We discovered that C. auris uses nutrient sensing to tune its virulence traits and modulate immune activation in changing environments. In glucose-rich conditions (relevant to blood), C. auris suppresses its virulence traits and evades immune detection. Conversely, non-fermentable carbon sources prevalent in skin activate adhesion and filamentation, thereby triggering macrophage responses. Activation of adhesion by non-fermentable carbon sources is recapitulated across diverse C. auris strains, while filamentation is heterogeneous. In-depth phenotyping of multiple clinical strains revealed that C. auris generates phenotypic heterogeneity by titrating expression of key transcriptional regulators dependent on nutrient inputs and genetic background. This modulates its virulence potential and controls proportional immune responses. Therefore, metabolic flexibility enables C. auris to optimize a critical trade-off: expressing virulence traits while minimizing immune recognition to colonize host tissues.

Indexed as

Candida aurisCandidiasisHost-Pathogen InteractionsNutrientsAnimalsGene Expression Regulation, FungalGlucoseHumansImmune EvasionMacrophagesMiceVirulenceGlucose

Identifiers

PMID42637889
PMCPMC13524834

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.