Evidence map›Paper›PMID 42637895›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Prenatal occupational exposure to quaternary ammonium compounds and birthweight: findings from a pilot study using meconium as a biological matrix.

Samantha Fisher, Brian Pavilonis, Homero Harari, Nadine Lahage, Arpit Gupta, Daniel Aguilar, Suzanne McDermott

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Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Samantha FisherCUNY Graduate School of Public Health and Health Policy, New York, NY, USA.
Brian PavilonisCUNY Graduate School of Public Health and Health Policy, New York, NY, USA. Brian.pavilonis@sph.cuny.edu.ORCID http://orcid.org/0000-0001-5065-3710
Homero HarariDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai 1 Gustave L. Levy Place New York, New York, NY, USA.
Nadine LahageDivision of Neonatal Perinatal Medicine, Department of Pediatrics, NYCHH Kings County Hospital and Downstate Health Sciences University, Brooklyn, NY, USA.ORCID http://orcid.org/0009-0004-1306-7199
Arpit GuptaDivision of Neonatal Perinatal Medicine, Department of Pediatrics, NYCHH Metropolitan Hospital Center, New York, NY, USA.
Daniel AguilarDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai 1 Gustave L. Levy Place New York, New York, NY, USA.
Suzanne McDermottCUNY Graduate School of Public Health and Health Policy, New York, NY, USA.

Funding

U.S. Department of Health & Human Services | CDC | National Institute for Occupational Safety and Health (NIOSH) T42OH008422
6 · The paper itself

Abstract

objectiveTo evaluate prenatal exposure to quaternary ammonium compounds (QACs) using meconium analysis and assess associations with newborn birthweight.

methodsWe analyzed meconium from 74 mother-infant dyads in two New York City public hospitals for 20 QACs using UPLC-MS. Principal component analysis (PCA) identified exposure patterns, and logistic regression assessed associations between PCA scores and birthweight at or below the 25th percentile, adjusting for maternal education and other factors.

resultsQACs were detected in over 99% of samples; C14-BAC was most prevalent. PCA revealed four components; PC1. represented the cumulative QACs burden. Higher PC1 scores were associated with increased odds of reduced birthweight (adjusted OR = 1.27; 95% CI: 1.02-1.58). Lower maternal education was also associated with decreased birthweight. Teachers had the highest PC1 scores, suggesting occupational exposure.

conclusionsPrenatal QACs exposure is widespread and may be linked to reduced birthweight. Occupational settings may contribute significantly to exposure, and disinfection practices should be reevaluated.

Identifiers

PMID42637895

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.