Evidence map›Paper›PMID 42638617›Full record

Trial reportAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Longitudinal effects of physical activity on sleep in association with hippocampal-amygdala subfield structure and functional connectivity in Alzheimer's disease.

Ravi Dadsena, Ana S Costa, Shari David, Luisa Haberl, Jörg B Schulz, Kathrin Reetz, Alexa Haeger

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ravi DadsenaCentre for Dementia and Prevention Aachen (ZDPA), Department of Neurology, RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0000-0001-7387-0750
Ana S CostaCentre for Dementia and Prevention Aachen (ZDPA), Department of Neurology, RWTH Aachen University, Aachen, Germany.
Shari DavidCentre for Dementia and Prevention Aachen (ZDPA), Department of Neurology, RWTH Aachen University, Aachen, Germany.
Luisa HaberlCentre for Dementia and Prevention Aachen (ZDPA), Department of Neurology, RWTH Aachen University, Aachen, Germany.
Jörg B SchulzCentre for Dementia and Prevention Aachen (ZDPA), Department of Neurology, RWTH Aachen University, Aachen, Germany.
Kathrin ReetzCentre for Dementia and Prevention Aachen (ZDPA), Department of Neurology, RWTH Aachen University, Aachen, Germany.
Alexa HaegerCentre for Dementia and Prevention Aachen (ZDPA), Department of Neurology, RWTH Aachen University, Aachen, Germany.

Funding

IRTG Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) 269953372/GRK2150Rotation Program and Short Term Program of the Faculty of Medicine, RWTH Aachen UniversityRWTH-Startup Grant from the Exploratory Research Space - ERS, RWTH Aachen University StUpPD_329-18Stiftung Universitätsmedizin Aachen
6 · The paper itself

Abstract

introductionSleep is a modifiable risk factor in Alzheimer's disease (AD), but its relationship to medial temporal lobe (MTL) subfields and responsiveness to lifestyle interventions remain unclear.

methodsIn the Dementia-Multi-Objective Validation of Exercise (MOVE) study, 46 individuals on the AD continuum were randomized to 6 months of multimodal exercise (n = 25) or psychoeducation (n = 21) and followed for 18 months (T1-T4). Clinical and cognitive testing, sleep/activity measures (PSQI, diaries, wearables), high-resolution T1, and resting-state functional magnetic resonance imaging scans were acquired. Hippocampal and amygdala subfield volumes and hippocampus-amygdala connectivity were analyzed longitudinally.

resultsAfter the 6-month intervention, the intervention group showed increased hippocampus-amygdala connectivity and attenuated subfield atrophy. One year later, both groups progressed in cognitive decline and hippocampal atrophy. Hippocampal and amygdalar volumes and connectivity were associated with sleep parameters as well as activity and cognitive parameters. DISCUSSION: Exercise was associated with short-term MTL preservation and network reorganization linked to sleep and activity, supporting continuous physical activity for lasting benefits.

Indexed as

Alzheimer DiseaseAmygdalaExerciseHippocampusSleepAgedAged, 80 and overAtrophyFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleNeural PathwaysNeuropsychological TestsAlzheimer's diseasecognitive declinefunctional connectivitymedial temporal lobe subfieldsneurodegenerationneuroimagingphysical activity interventionresting statesleep

Identifiers

PMID42638617
PMCPMC13504447

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.