ArticleFrontiers in pain research (Lausanne, Switzerland)2026
Force-based manipulation via wearable focal vibration for pain relief and changes in gait biomechanics in diabetic peripheral neuropathy: a secondary analysis of a pilot trial.
Article in Frontiers in pain research (Lausanne, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Diabetic peripheral neuropathy (DPN) disrupts somatosensory feedback, causing chronic pain, altered gait mechanics, and elevated fall risk. While force-based manipulations are known to modulate nociception and proprioception, their biomechanical effects and clinical efficacy in DPN remain underexplored. This secondary analysis investigated the effects of a wearable, force-based focal vibration therapy (FVT) on pain relief, estimated fall risk category, and gait performance in adults with DPN. Methods: We analyzed data from our single-blinded, parallel-group pilot trial of 28 participants (Experimental Group [EG], Results: The force-based intervention yielded exceptional compliance. In the EG, FVT significantly reduced pain interference with walking ( Conclusion: Targeted force-based manipulation via wearable FVT offers a highly feasible mechanism for pain relief and changes in gait biomechanics in DPN. By uncoupling neuropathic pain from functional ambulation, this intervention provides preliminary, hypothesis-generating evidence that supports the need for further investigation in fully powered trials.
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