ReviewJournal of inflammation research2026
Beyond Drainage: How Lymphatic Vessels Instruct Immune Cell Fate.
Review in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lymphatic vasculature is increasingly recognized as not only a passive drainage network but also an active regulator of immune cell fate. This regulation operates through two complementary modes. In the direct mode, lymphatic endothelial cells engage immune cells through checkpoint signaling, antigen presentation, and adhesion-dependent transendothelial migration, thereby regulating the deletion, anergy, and differential trafficking of regulatory and effector T cells. In the indirect mode, biomechanical cues (including interstitial flow, interstitial fluid pressure, and dynamic switching of endothelial junctions between button-like and zipper-like states), along with chemokine gradients, govern the selective delivery of immune cells and antigens to draining lymph nodes and the kinetics of this process. Both direct and indirect modes are shaped by the local tissue microenvironment, and their remodeling during inflammation and cancer can favor either immune priming or immunosuppression. When these two modes are considered as an integrated, coupled system rather than separate processes, the context-specific advantages and limitations of lymphatic-targeted immunomodulation can be evaluated.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.