Evidence map›Paper›PMID 42639435›Full record

ArticleOncology letters2026

Flavokawain A inhibits high glucose-induced malignant progression of lung cancer cells by suppressing PRMT5-mediated PTEN neddylation and nuclear translocation.

Lei Zheng, Juan Li, Chao Song, Leping Shi, Qian Zhou, Yuyao Guan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lei ZhengDepartment of Pharmacy, Shandong Provincial Third Hospital, Shandong University, Jinan, Shandong 250013, P.R. China.
Juan LiDepartment of Pharmacy, The Second Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong 250033, P.R. China.
Chao SongDepartment of Pharmacy, Shandong Provincial Third Hospital, Shandong University, Jinan, Shandong 250013, P.R. China.
Leping ShiDepartment of Pharmacy, Shandong Provincial Third Hospital, Shandong University, Jinan, Shandong 250013, P.R. China.
Qian ZhouDepartment of Pharmacy, Shandong Provincial Third Hospital, Shandong University, Jinan, Shandong 250013, P.R. China.
Yuyao GuanDepartment of Pharmacy, Shandong Provincial Third Hospital, Shandong University, Jinan, Shandong 250013, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A high-glucose microenvironment is a key feature of tumor metabolic reprogramming that promotes lung cancer cell progression. Previous studies have revealed that protein arginine methyltransferase 5 (PRMT5) is overactivated in various cancers and regulates neddylation of the tumor suppressor phosphatase and tensin homolog (PTEN). This study established a high-glucose (25 mM)

Indexed as

flavokawain Ahigh glucoseneddylationphosphatase and tensin homolog

Identifiers

PMID42639435
PMCPMC13501492

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.