ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2026
Baihe Dihuang decoction activates cannabinoid type 2 receptor to regulate microglial polarization and alleviate anxiety-like behavior in chronic restraint stress mice.
Luo Qiaoyun, Han Yuanshan, Liu Yang, Tang Lin, Wang Tianyu, Wang Yuhong, Zhao Hongqing
Abstract read
In one paragraphArticle in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
7 authors.
Luo QiaoyunSchool of Pharmacy, Hunan University of Chinese Medicine, Changsha410208, China.
Han YuanshanDrug Clinical Research Center, the First Hospital, Hunan University of Chinese Medicine, Changsha410007, China.
Liu YangAcademy of Chinese Medical Sciences/Science & Technology Innovation Center, Hunan University of Chinese Medicine, Changsha410208, China.
Tang LinPharmaceutical Preparation Center, the first affiliated Hospital, Hunan University of Chinese Medicine, Changsha410007, China.
Wang TianyuSchool of Pharmacy, Hunan University of Chinese Medicine, Changsha410208, China.
Wang YuhongAcademy of Chinese Medical Sciences/Science & Technology Innovation Center, Hunan University of Chinese Medicine, Changsha410208, China.
Zhao HongqingAcademy of Chinese Medical Sciences/Science & Technology Innovation Center, Hunan University of Chinese Medicine, Changsha410208, China.
Funding
Mechanism Study of Baihe Dihuang Decoction in Improving Synaptic Homeostasis of Basolateral Amygdala-ventral Hippocampus in Anxious Depression by Regulating Microglial Function Cannabinoid Type 2 Receptor 2026JJ50265National Natural Science Foundation of China: Mechanism Study of Baihe Dihuang Decoction in Ameliorating Neural Pathway Injury of Basolateral Amygdala-Ventral Hippocampus in Anxious Depression Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 2 82104836Natural Science Foundation of Hunan Province: Study on the Mechanism of Anxiolytic Mechanism of Baihe Dihuang Decoction by Activating Cannabinoid Type 2 Receptor to Regulate the Polarization Phenotype of Microglia 2023JJ60482Open Fund of National Key Laboratory Cultivation Base of Chinese Medicinal Powder & Innovative Medicinal Jointly Established by Province and Ministry: Mechanism of Anxiolytic Neural Circuitry of Baihe Jielü Anshen Granules was Studied Based on Basolateral Amygdala to Nucleus Accumbens Neuronal Excitation/Inhibition Imbalance 25PTKF1002Science and Technology Talent Promotion Project of Hunan Province: Young and Talented Science and Technology Talent Development Program 2023TJ-N22Scientific Research Project of Hunan Provincial Department of Education: Scientific Research Project of Hunan Provincial Department of Education: Mechanism of Excitatory/Inhibitory Imbalance of Spiny Neurons in Basolateral Amygdala to Nucleus Accumbens Neural Circuit Inducing Anxiety and Intervention Research of Baihe Shugan Anshen Tablets 23B0391
6 · The paper itselfAbstract
objectiveTo investigate the anxiolytic effects of Baihe Dihuang decoction (, BDD) and its underlying molecular mechanisms, focusing on cannabinoid type 2 receptor (CB2R)-mediated regulation of microglial polarization and the toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/nuclear factor-kappa B (NF-κB) signaling pathway.
methodsA total of 60 male C57BL/6J mice were randomly divided into six groups (
resultsBDD significantly alleviated CRS-induced anxiety-like behaviors and reduced neuronal damage in the amygdala. It downregulated pro-inflammatory cytokines IL-1β, IL-6 and upregulated anti-inflammatory cytokines IL-10, IL-4 in serum while increasing 2-AG and AEA levels in the amygdala. Furthermore, BDD promoted microglial polarization toward the M2 phenotype and enhanced CB2R expression, while suppressing the TLR4/MyD88/NF-κB signaling pathway. The administration of the CB2R antagonist AM630 reversed these effects, confirming the essential role of CB2R activation in the anxiolytic and neuroprotective effects of BDD.
conclusionBDD treatment activated CB2R, which in turn modulated microglial polarization in the amygdala
Indexed as
AnxietyDrugs, Chinese HerbalMicrogliaReceptor, Cannabinoid, CB2AnimalsAnti-Anxiety AgentsHumansInterleukin-6MaleMiceMice, Inbred C57BLMyeloid Differentiation Factor 88NF-kappa BRestraint, PhysicalSignal TransductionToll-Like Receptor 4Anti-Anxiety AgentsDrugs, Chinese HerbalInterleukin-6Myeloid Differentiation Factor 88NF-kappa BReceptor, Cannabinoid, CB2Toll-Like Receptor 4anti-anxiety agentsanxiety disordersBaihe Dihuang decoctionmicroglial polarizationneuroinflammatory diseasesreceptor, cannabinoid, CB2
Identifiers
PMID42639765
PMCPMC13494881
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