Evidence map›Paper›PMID 42639772›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2026

Taohong Huazhuo decoction alleviates carbon tetrachloride-induced hepatic fibrosis in rats by inhibiting the nicotinamide adenine dinucleotide phosphate oxidase 4/nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 signaling pathway.

Ren Yuan, Chen Xiangni, Shi Lei, Mao Minghua, L I Shufang, Yao Jia, Hao Jianmei

Abstract read
In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ren YuanDepartment of Hepatology, Xi'an Hospital of Traditional Chinese Medicine, Xi'an710021, China.
Chen XiangniDepartment of Hepatology, Xi'an Hospital of Traditional Chinese Medicine, Xi'an710021, China.
Shi LeiDepartment of Hepatology, Xi'an Hospital of Traditional Chinese Medicine, Xi'an710021, China.
Mao MinghuaDepartment of Hepatology, Xi'an Hospital of Traditional Chinese Medicine, Xi'an710021, China.
L I ShufangDepartment of Hepatology, Xi'an Hospital of Traditional Chinese Medicine, Xi'an710021, China.
Yao JiaExperimental Center, Xi'an Hospital of Traditional Chinese Medicine, Xi'an710021, China.
Hao JianmeiDepartment of Hepatology, Xi'an Hospital of Traditional Chinese Medicine, Xi'an710021, China.

Funding

Cultivation Projects of the National Natural Science Foundation of Xi'an Traditional Chinese Medicine Hospital: Exploring the Molecular Mechanism of Taohong Huazhuo decoction Against Liver Fibrosis Based on Endoplasmic Reticulum Stress-mediated Ferroptosis 2024YJ02Youth Program of Xi'an Municipal Health Commission of China: Exploring the Molecular Mechanism of Taohong Huazhuo decoction in Improving Liver Fibrosis by Regulating the Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2/Reactive Oxygen Species Signaling Pathway Based on the Theory of Damp-heat and Ministerial Fire 2024qn20
6 · The paper itself

Abstract

objectiveTo explore the mechanism underlying the anti-fibrotic effects of Taohong Huazhuo decoction (THHZD, ).

methodsForty percent carbon tetrachloride (CCl

resultsTHHZD improved the pathological changes caused by CCl

conclusionTHHZD reduced the activation of HSCs by inhibiting the NOX4/NLRP3 signaling pathway, thereby exerting anti-hepatic fibrosis effects.

Indexed as

Drugs, Chinese HerbalLiver CirrhosisNADPH Oxidase 4NLR Family, Pyrin Domain-Containing 3 ProteinAnimalsCarbon TetrachlorideHepatic Stellate CellsHumansInterleukin-18Interleukin-1betaLiverMaleRatsRats, Sprague-DawleyReactive Oxygen SpeciesSignal TransductionCarbon TetrachlorideDrugs, Chinese HerbalInterleukin-18Interleukin-1betaNADPH Oxidase 4NLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratNox4 protein, ratReactive Oxygen Specieshepatic fibrosishepatic stellate cellsTaohong Huazhuo decoction

Identifiers

PMID42639772
PMCPMC13494871

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.