ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2026
Antihypertensive effect of acupuncture involve reshaping gut microbiota and alleviating gut inflammation in spontaneously hypertensive rats.
Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the antihypertensive effect and mechanism of acupuncture at Renying (ST9) and Zusanli (ST36) from the perspective of gut microbiota.
methodsEighteen male spontaneously hypertensive rats (SHRs) were randomly divided into the SHR group, the acupuncture group (SHR + A), the sham acupuncture group (SHR + SA), and six Wistar-Kyoto rats were set up as the normotensive control group. 16S ribosomal ribonucleic acid gene sequencing was performed to characterize changes in the gut microbiota. Blood samples were collected to measure inflammatory cytokines using enzyme-linked immunosorbent assay. Hematoxylin and eosin staining was used to assess the degree of colonic damage. Western blotting was performed to evaluate intestinal inflammation.
resultsWe observed that acupuncture at acupoints Renying (ST9) and Zusanli (ST36) reduced blood pressure in SHRs, modulated microbial beta diversity, increased the abundance of beneficial genera, and reshaped the composition of the intestinal microbiota. In addition, hypertension induced pathological changes in the intestine, along with inflammation and increased permeability. By contrast, acupuncture treatment decreased serum inflammatory cytokine levels and inhibited activation of the toll-like receptor 4/ nuclear factor-kappa B signaling pathway in SHRs, thereby restoring intestinal barrier integrity.
conclusionsOur experimental results indicate that acupuncture exerts a hypotensive effect that is associated with modulation of intestinal inflammation and microbiota, which may offer a new strategy for the prevention and treatment of hypertension.
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