Evidence map›Paper›PMID 42639787›Full record

ReviewJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2026

Intranasal essential oils in therapy: advances in clinical applications and delivery mechanisms.

Liang Yong, Guan Qiuyan, Chen Yi, W U Wei, Yang Ming, Tang Fangrui, Wang Yawen, Pan Deng, Huang Xiaoying, L I Huiting

Abstract readReview
In one paragraph

Review in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Liang YongKey Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang330004, China.
Guan QiuyanKey Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang330004, China.
Chen YiKey Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang330004, China.
W U WeiKey Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang330004, China.
Yang MingKey Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang330004, China.
Tang FangruiKey Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang330004, China.
Wang YawenKey Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang330004, China.
Pan DengKey Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang330004, China.
Huang XiaoyingKey Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang330004, China.
L I HuitingKey Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang330004, China.

Funding

Doctoral Research Startup Fund Project of Jiangxi University of Traditional Chinese Medicine: Research on Process Control Strategies for the "Release-Stabilization" of Essential Oils Based on Volatility and Pyrolyzability, Optimization of Microbial Fermentation Process for Fengyan Aurantii Fructus 2024BSZR005Doctoral Research Startup Fund Project of Jiangxi University of Traditional Chinese Medicine: Research on Process Control Strategies for the "Release-Stabilization" of Essential Oils Based on Volatility and Pyrolyzability, Optimization of Microbial Fermentation Process for Fengyan Aurantii Fructus 2024BSZR016Hainan Province Science and Technology Special Fund: Research on the Chemical Basis of Aroma Formation and High-value Utilization of Hainan Agarwood ZDYF2025SHFZ055Key R & D Projects of Ganjiang New District in Jiangxi Province: Development and Application of "Scent Stabilization" Technology for Essential Oils 2023007National College Students' Innovation and Entrepreneurship Training Program in 2024: Yunding Fragrance-Traditional Chinese Medicine (TCM) Scalp Therapy Essential Oil 202410412007National Natural Science Foundation of China: Research on Stabilization Control Strategies of Essential Oils Based on "Porous Adsorption-Size Sieving-Structural Controlled Release" 82404878Natural Science Foundation of Jiangxi Province: Research on the Design of Mesoporous Material-Loaded Essential Oil Solidified Powders and Their Stabilization Application in Tablets 20242BAB20456Provincial College Students' Innovation and Entrepreneurship Training Program in 2024: Yinyang Zhihe-a TCM Compound Essential Oil Pillow Sheet for Insomnia Caused by Liver Fire Disturbing the Heart S202410412094Science and Technology Research Project of Jiangxi Education Department: Research on the Degradation of Traditional Chinese Medicine Wastewater by Hydrotalcite-Based Photocatalysts GJJ211258
6 · The paper itself

Abstract

This review comprehensively examines the therapeutic mechanisms, formulation advancements, and clinical applications of intranasal essential oil (EO) delivery, aiming to highlight its potential as a modern therapeutic approach. A systematic literature search was conducted in PubMed and Web of Science up to May 2024, focusing on preclinical and clinical studies. Data on target diseases, delivery mechanisms, formulation innovations, and therapeutic effects were extracted and analyzed. Intranasal EO delivery demonstrates significant therapeutic potential for neurological, respiratory, cardiovascular, and metabolic disorders. Advanced delivery systems, including nanoemulsions, liposomes, and nasal in situ gels, enhance EO stability, bioavailability, and targeted release. Mechanistically, EOs exert effects through neurotransmission modulation, anti-inflammatory pathways, and vascular regulation, primarily

Indexed as

Drug Delivery SystemsOils, VolatileAdministration, IntranasalAnimalsHumansOils, Volatileintranasal deliverymedicinal effectoils, volatilereviewtherapeutic mechanisms

Identifiers

PMID42639787
PMCPMC13494891

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.