Evidence map›Paper›PMID 42640025›Full record

ArticleActa physiologica (Oxford, England)2026

Immune-Induced Fever and Psychogenic Hyperthermia Can Occur Independently of Uncoupling Protein 1-Mediated Brown Adipose Tissue Thermogenesis.

Takashi Matsuwaki, Wakana Harigai, Vladimir Maksimov, Yutaro Nakayama, Kazuyuki Uchida, James K Chambers, Keitaro Yamanouchi, Anna Eskilsson, Anders Blomqvist

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta physiologica (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Takashi MatsuwakiLaboratory of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-4842-6110
Wakana HarigaiLaboratory of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0001-8177-1744
Vladimir MaksimovDivision of Neurobiology, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.ORCID https://orcid.org/0000-0002-4029-8257
Yutaro NakayamaLaboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Kazuyuki UchidaLaboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0003-4823-0318
James K ChambersLaboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0001-5273-7221
Keitaro YamanouchiLaboratory of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-1491-5127
Anna EskilssonDivision of Neurobiology, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.ORCID https://orcid.org/0000-0002-6131-0403
Anders BlomqvistDivision of Neurobiology, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.ORCID https://orcid.org/0000-0002-6928-4473

Funding

Japan Society for the Promotion of Science 22H00396Japan Society for the Promotion of Science 23KK0126JSPS-STINT JA2018-7623JSPS-STINT JPJSBP120195406Swedish Brain Foundation FO2025-0110-HK-175
6 · The paper itself

Abstract

aimBrown adipose tissue thermogenesis is widely considered an important effector mechanism in fever and emotionally induced hyperthermia (psychogenic fever), and increases in interscapular temperature are commonly interpreted as evidence of brown adipose tissue activation. Yet direct evidence for this interpretation remains limited and conflicting. Here, we tested these assumptions using complementary genetic and surgical approaches in rats.

methodsWe generated uncoupling protein 1 knockout rats, in which canonical brown adipose tissue thermogenesis is abolished, and examined body temperature responses to systemic inflammation induced by lipopolysaccharide and to emotional stressors, including restraint and cage exchange. In separate experiments, interscapular brown adipose tissue was surgically removed in wild-type rats.

resultsDespite profound impairment of cold- and β

conclusionFever and psychogenic hyperthermia in rats do not require uncoupling protein 1-mediated brown adipose tissue thermogenesis. Furthermore, increases in interscapular temperature are not necessarily indicative of brown adipose tissue thermogenesis, challenging a widely held interpretation of these phenomena.

Indexed as

Adipose Tissue, BrownFeverHyperthermiaIon ChannelsThermogenesisAnimalsBody TemperatureMaleRatsUncoupling Protein 1Ion ChannelsUcp1 protein, ratUncoupling Protein 1brown adipose tissuefeverpsychogenic hyperthermiaratuncoupling protein 1

Identifiers

PMID42640025
PMCPMC13505244

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.