Evidence map›Paper›PMID 42640083›Full record

SynthesisDiabetes/metabolism research and reviews2026

Left Ventricular Global Longitudinal Strain as a Marker of Subclinical Myocardial Dysfunction in Youths With Type 1 Diabetes Mellitus: An Updated Systematic Review and Meta-Analysis.

Athina Stamati, Georgia Sotiriou, Elpida Emmanoulidou-Fotoulaki, Nikoleta Printza, Maria Kavga, Athanasios Christoforidis

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Diabetes/metabolism research and reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Athina StamatiFaculty of Health Science, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID https://orcid.org/0000-0002-4827-2350
Georgia Sotiriou1st Paediatric Department, Faculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, Ippokratio General Hospital, Thessaloniki, Greece.ORCID https://orcid.org/0009-0002-4554-3116
Elpida Emmanoulidou-Fotoulaki1st Paediatric Department, Faculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, Ippokratio General Hospital, Thessaloniki, Greece.ORCID https://orcid.org/0000-0002-8560-967X
Nikoleta Printza1st Paediatric Department, Faculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, Ippokratio General Hospital, Thessaloniki, Greece.
Maria Kavga3rd Paediatric Department, Faculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, Ippokratio General Hospital, Thessaloniki, Greece.ORCID https://orcid.org/0000-0001-9224-0922
Athanasios Christoforidis1st Paediatric Department, Faculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, Ippokratio General Hospital, Thessaloniki, Greece.ORCID https://orcid.org/0000-0003-4964-5726

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo assess Left Ventricular Global Longitudinal Strain (LV GLS) in youths with type 1 diabetes mellitus (T1DM) compared with healthy controls, as a marker of subclinical myocardial dysfunction.

methodsWe searched MEDLINE, the Cochrane Library, Scopus and the Web of Science up to November 2025 for studies comparing speckle-tracking-derived LV GLS in paediatric T1DM and healthy controls. Random-effects meta-analyses focused on two-dimensional LV GLS, with exploratory three-dimensional analyses, vendor-based subgroup analyses and meta-regression for age, diabetes duration and HbA1c.

resultsTwenty studies met the inclusion criteria. Eighteen studies (1086 youths with T1DM, 935 controls) were included in the primary 2D LV GLS analysis. Compared with controls, youth with T1DM had significantly impaired 2D LV GLS (mean difference -2.87%, 95% CI -4.03 to -1.71), with substantial heterogeneity (I

conclusionChildren and adolescents with T1DM show impaired left ventricular longitudinal deformation despite preserved conventional systolic indices, indicating early subclinical myocardial dysfunction. However, given the substantial heterogeneity and low certainty of current evidence, future standardized longitudinal studies are warranted. Ultimately, with the increasing use of speckle-tracking echocardiography, GLS may serve as a valuable tool for cardiovascular risk stratification in this population.

Indexed as

BiomarkersDiabetes Mellitus, Type 1Diabetic CardiomyopathiesGlobal Longitudinal StrainVentricular Dysfunction, LeftAdolescentChildEchocardiographyHumansBiomarkersglobal longitudinal strainmeta‐analysismyocardial dysfunctionsystematic reviewtype 1 diabetes mellitus

Identifiers

PMID42640083
PMCPMC13505227

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.