Evidence map›Paper›PMID 42642334›Full record

ArticleCancer science2026

Psychological Stress Promotes Tumor Growth in Hepatocellular Carcinoma Models Through Myeloid Signaling.

Keita Ogawa, Takahiro Aoki, Tatsuya Kaneko, Hongxuan Wang, Daiki Shimizu, Daisuke Katsumi, Iori Kojima, Hidekazu Tanaka, Kiwamu Motoyoshi, Ko Ozaki and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Keita OgawaDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Takahiro AokiDepartment of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID https://orcid.org/0000-0002-9148-2871
Tatsuya KanekoDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Hongxuan WangDepartment of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Daiki ShimizuDepartment of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Daisuke KatsumiDepartment of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Iori KojimaDepartment of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Hidekazu TanakaDepartment of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Kiwamu MotoyoshiDepartment of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Ko OzakiDepartment of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Katsuhiro NishimuraDepartment of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Tomohisa IinumaDepartment of Otorhinolaryngology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Mariko TakamiDepartment of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Shinichiro MotohashiDepartment of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID https://orcid.org/0000-0002-9332-3129

Funding

Leading Graduate School "Nurture of Creative Research Leaders in Immune System Regulation and Innovative Therapeutics"Research Institute of Disaster Medicine
6 · The paper itself

Abstract

Psychological stress has long been implicated in cancer progression, yet the underlying biological pathways remain incompletely understood. In particular, the influence of stress on myeloid cells remains poorly explored. Here, we demonstrate that restraint stress accelerates hepatocellular carcinoma (HCC) progression through coordinated regulation of macrophages and neutrophils. Across sexes and strains, stressed mice exhibited enhanced tumor growth accompanied by marked neutrophil infiltration and elevated expression of neutrophil-attracting chemokines. Integrative analyses combining single-cell transcriptomics and in vitro experiments identified macrophages as the dominant producers of these chemokines and revealed that β

Indexed as

beta‐2 adrenergic receptorhepatocellular carcinomamacrophagesneutrophilpsychological stress

Identifiers

PMID42642334
PMCPMC13506269

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.