Evidence map›Paper›PMID 42642368›Full record

ArticleNature communications2026

Functional immune changes are conserved in COVID-19 and trauma patients receiving intensive care.

Alexander J T Wood, Gesa J Albers, Willem Cornelissen, James D Maiden, Deirdre E Cuff, Mitra Ashayeripanah, Patrick Schriek, Samantha J Emery-Corbin, Nichollas E Scott, Shihan Li and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alexander J T WoodDepartment of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia. alexander.wood@health.wa.gov.au.ORCID http://orcid.org/0000-0001-7819-0447
Gesa J AlbersDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-8249-6956
Willem CornelissenDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
James D MaidenDepartment of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia.ORCID http://orcid.org/0009-0003-1555-6634
Deirdre E CuffDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Mitra AshayeripanahDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Patrick SchriekDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Samantha J Emery-CorbinMonash Proteomics & Metabolomics Platform, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Nichollas E ScottDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0003-2556-8316
Shihan LiComputational Sciences Initiative, the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Jan SchröderComputational Sciences Initiative, the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Adam M DeaneDepartment of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia.
Jose A VilladangosDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia. j.villadangos@unimelb.edu.au.ORCID http://orcid.org/0000-0001-6771-8891
Laura CookDepartment of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia. l.cook@unimelb.edu.au.ORCID http://orcid.org/0000-0003-3153-2045

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Critical illness, including COVID-19 and trauma, induce immune dysregulation associated with morbidity and mortality. Direct comparison is crucial to identify shared pathobiological mechanisms to guide precision therapies. This prospective cohort study undertook a comprehensive, longitudinal comparison of innate immune cell function and plasma protein expression in critically ill patients at days 1, 3, and 5 of intensive care unit admission. We enrolled 26 COVID-19 patients, 20 trauma patients, and 18 healthy controls and analysed plasma proteins and immune cell phenotypes and responses to S. aureus bioparticles. An unsupervised multi-omics factor analysis (MOFA) identified shared sources of biological variation. Here we show shared, profound immune alterations, including neutrophilia, decreased non-classical monocytes and dendritic cells (DCs), and a hyper-phagocytic and reactive oxygen species producing neutrophil state in both patient cohorts compared to healthy controls. Classical monocytes from patients were unable to upregulate CD11c, CD86, and SIRPα upon stimulation, and a phagocytosis-impaired SIRPα

Indexed as

COVID-19Wounds and InjuriesAdultAgedCritical CareCritical IllnessDendritic CellsFemaleHumansImmunity, InnateIntensive Care UnitsMaleMiddle AgedMonocytesNeutrophilsPhagocytosis

Identifiers

PMID42642368
PMCPMC13507279

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.