Evidence map›Paper›PMID 42642414›Full record

ArticleNature communications2026

IFI208, an interferon-stimulated gene, promotes host antiviral responses through liquid-liquid phase separation of MDA5.

Guangqiang Ye, Jiaxiu Gao, Xiaohong Liu, Qiongqiong Zhou, Li Huang, Haoxuan Cao, Guihong Zhang, Zhaoxia Zhang, Hongyang Liu, Changjiang Weng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Guangqiang Ye *Division of Fundamental Immunology, State Key Laboratory of Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
Jiaxiu Gao *Division of Fundamental Immunology, State Key Laboratory of Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
Xiaohong LiuDivision of Fundamental Immunology, State Key Laboratory of Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
Qiongqiong ZhouDivision of Fundamental Immunology, State Key Laboratory of Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
Li HuangDivision of Fundamental Immunology, State Key Laboratory of Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
Haoxuan CaoKey Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Guihong ZhangKey Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.ORCID http://orcid.org/0000-0002-1212-265X
Zhaoxia ZhangDivision of Fundamental Immunology, State Key Laboratory of Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
Hongyang LiuDivision of Fundamental Immunology, State Key Laboratory of Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China. liuhongyang@caas.cn.ORCID http://orcid.org/0009-0002-9864-1633
Changjiang WengDivision of Fundamental Immunology, State Key Laboratory of Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China. wengchangjiang@caas.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PYHIN (IFI200/HIN-200) family members are involved in host antiviral immune responses by detecting viral nucleic acids through HIN domains. Within this family, the function of IFI208, which lacks a HIN domain, remains largely unknown. In this study, we identify IFI208, a member of the PYHIN family, as an interferon stimulated gene (ISG). Upon exposure to viral DNA and RNA, IFI208 inhibits viral replication by increasing type I interferon (IFN) production. Mechanistically, upon infection, IFI208 is translocated to the cytoplasm through the chromosome region maintenance 1 (XPO1) transporter protein, and interacts with melanoma differentiation associated gene 5 (MDA5) to enhance the ability of this protein to recognize double stranded RNA (dsRNA) and promote its oligomerization. Taken together, we identify IFI208 as an interferon-stimulated gene (ISG) that induces dsRNA dependent liquid-liquid phase separation of MDA5. Our results indicate that the XPO1-IFI208-MDA5 axis has an important function in the innate responses to viruses.

Indexed as

Interferon-Induced Helicase, IFIH1AnimalsExportin 1 ProteinHEK293 CellsHumansImmunity, InnateInnate Immunity RecognitionInterferon Type IKaryopherinsPhase SeparationReceptors, Cytoplasmic and NuclearRNA, Double-StrandedVirus ReplicationExportin 1 ProteinIFIH1 protein, humanInterferon-Induced Helicase, IFIH1Interferon Type IKaryopherinsReceptors, Cytoplasmic and NuclearRNA, Double-Stranded

Identifiers

PMID42642414
PMCPMC13507083

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.