ArticleAging cell2026
Aging-Related Myocardial Susceptibility Lowers Cardiac Tolerance to Chronic Intermittent Hypoxia Through Dynamin-Related Protein 1-Associated Mitochondrial Vulnerability.
Yinghui Su, Yuyang Miao, Jin Tan, Feng Wang, Qiang Zhang
Abstract read
In one paragraphArticle in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
5 authors.
Yinghui SuDepartment of Geriatrics, Tianjin Medical University General Hospital, Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration in the Central Nervous System, Ministry of Education, State Key Laboratory of Experimental Hematology, Tianjin Key Laboratory of Elderly Health, Tianjin Geriatrics Institute, Tianjin, People's Republic of China.ORCID https://orcid.org/0009-0001-5229-0164 Yuyang MiaoDepartment of Geriatrics, Tianjin Medical University General Hospital, Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration in the Central Nervous System, Ministry of Education, State Key Laboratory of Experimental Hematology, Tianjin Key Laboratory of Elderly Health, Tianjin Geriatrics Institute, Tianjin, People's Republic of China.ORCID https://orcid.org/0000-0002-4453-9687 Jin TanDepartment of Geriatrics, Tianjin Medical University General Hospital, Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration in the Central Nervous System, Ministry of Education, State Key Laboratory of Experimental Hematology, Tianjin Key Laboratory of Elderly Health, Tianjin Geriatrics Institute, Tianjin, People's Republic of China.
Feng WangDepartment of Genetics, School of Basic Medical Science, Tianjin Medical University, The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin, People's Republic of China.ORCID https://orcid.org/0009-0007-5238-8704 Qiang ZhangDepartment of Geriatrics, Tianjin Medical University General Hospital, Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration in the Central Nervous System, Ministry of Education, State Key Laboratory of Experimental Hematology, Tianjin Key Laboratory of Elderly Health, Tianjin Geriatrics Institute, Tianjin, People's Republic of China.ORCID https://orcid.org/0000-0002-5686-9253 Funding
National Key Research and Development Program of China 2023YFC3605200National Natural Science Foundation of China U25A2002Tianjin Key Medical Discipline Construction Project TJYXZDXK-3-005C
6 · The paper itselfAbstract
Chronic intermittent hypoxia (CIH), a cardinal pathophysiological feature of obstructive sleep apnea (OSA), repeatedly exposes the heart to hypoxia-reoxygenation stress. The cardiac outcome of CIH, however, may depend on the biological state of the target myocardium. Here, we investigated whether a pre-existing aging-related myocardial susceptibility lowers the tolerance threshold for CIH-induced injury and whether Dynamin-related protein 1 (Drp1) contributes to the enhanced vulnerability of senescence-like cardiomyocytes under CIH. Using G3 Tert-deficient (Tert
Indexed as
AgingDynaminsHypoxiaMitochondriaMyocardiumAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutMyocytes, CardiacOxidative StressDnm1l protein, mouseDynaminscardiomyocytechronic intermittent hypoxia (CIH)dynamin‐related protein 1 (Drp1)mitochondriamyocardiumsenescence
Identifiers
PMID42642787
PMCPMC13507029
What Socratic holds
Textmetadata
Read underepoch 390