Evidence map›Paper›PMID 42643032›Full record

ArticleMediators of inflammation2026

Integrative Single-Cell and Spatial Transcriptomics Identifies CRIP1

Zikang Xie, Yu Wang, Jinzhu Liu, He Li, Huwei Bian, Chonghao Gu

Abstract read
In one paragraph

Article in Mediators of inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zikang XieDepartment of Orthopedics, Changzhou Hospital of Traditional Chinese Medicine, Changzhou Affiliated Hospital of Nanjing University of Chinese Medicine, Changzhou, Jiangsu, China, czzyy.com.ORCID https://orcid.org/0009-0003-0051-1126
Yu WangDepartment of Orthopedics, Changzhou Hospital of Traditional Chinese Medicine, Changzhou Affiliated Hospital of Nanjing University of Chinese Medicine, Changzhou, Jiangsu, China, czzyy.com.
Jinzhu LiuDepartment of Orthopedics, Changzhou Hospital of Traditional Chinese Medicine, Changzhou Affiliated Hospital of Nanjing University of Chinese Medicine, Changzhou, Jiangsu, China, czzyy.com.
He LiDepartment of Orthopedics, Changzhou Hospital of Traditional Chinese Medicine, Changzhou Affiliated Hospital of Nanjing University of Chinese Medicine, Changzhou, Jiangsu, China, czzyy.com.
Huwei BianDepartment of Orthopedics, Changzhou Hospital of Traditional Chinese Medicine, Changzhou Affiliated Hospital of Nanjing University of Chinese Medicine, Changzhou, Jiangsu, China, czzyy.com.
Chonghao GuDepartment of Orthopedics, Changzhou Hospital of Traditional Chinese Medicine, Changzhou Affiliated Hospital of Nanjing University of Chinese Medicine, Changzhou, Jiangsu, China, czzyy.com.

Funding

Changzhou Municipal Talent Work Leading Group Office for the "14th Five-Year Plan" High-Level Health Personnel Training Program of Changzhou 2024CZBJ031Jiangsu Association of Chinese Medicine (JSACM) ZXFZ2026077
6 · The paper itself

Abstract

Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by progressive cartilage destruction, yet the heterogeneity of transitional chondrocyte states and their contributions to pathogenesis remain incompletely understood. In this study, we constructed a single-cell transcriptomic atlas of human knee cartilage from 16 OA samples and 2 non-OA normal donors. High-resolution sub-clustering of the prehypertrophic chondrocytes (preHTC) compartment revealed eight transcriptionally distinct subtypes, among which CRIP1

Indexed as

BiomarkersChondrocytesOsteoarthritisHumansInflammationSignal TransductionSingle-Cell AnalysisSingle-Cell Gene Expression AnalysisSpatial TranscriptomicsTranscriptomeBiomarkerschondrocyte heterogeneitydiagnostic modelmachine learningosteoarthritissingle-cell transcriptomics

Identifiers

PMID42643032
PMCPMC13507712

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.