Evidence map›Paper›PMID 42643254›Full record

ArticleJHLT open2026

The impact of preoperative mechanical support on long-term survival following early lung re-transplantation for graft failure.

Vikram Krishna, Allen A Razavi, Brian Lim, Zachary Brennan, Qiudong Chen, Joanna Chikwe, Michael E Bowdish, Laura DiChiacchio, Reinaldo Rampolla, Dominick Megna and 1 more

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In one paragraph

Article in JHLT open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vikram KrishnaDepartment of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Allen A RazaviDepartment of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Brian LimDepartment of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Zachary BrennanDepartment of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Qiudong ChenDivision of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.
Joanna ChikweDepartment of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Michael E BowdishDepartment of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Laura DiChiacchioDepartment of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Reinaldo RampollaDepartment of Pulmonary and Critical Care Medicine, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, California.
Dominick MegnaDepartment of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Pedro CatarinoDepartment of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.

Funding

Training in Advanced Heart Disease ResearchT32HL116273 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI Joshua I Goldhaber, EDUARDO MARBAN · 2013 to 2026
$5.6M
NHLBI NIH HHS T32 HL116273
6 · The paper itself

Abstract

Objective: Severe graft failure after lung transplantation is a devastating outcome with limited therapeutic options. Mechanical support provides temporary stabilization but may compromise re-transplantation candidacy. This study examined postoperative outcomes and long-term survival of graft failure re-transplants by preoperative mechanical support use. Methods: The UNOS database was queried for adults undergoing early re-transplantation for graft failure (EGF) performed within 1 year of the primary transplant from 2005 to 2025. Primary transplants, multiorgan, and re-transplants from unknown causes were excluded. Patients were stratified by preoperative mechanical support use (ventilation and/or ECMO). The primary outcome was 5-year survival. Results: Among 1453 re-transplants, 140 (9.6%) were for EGF. 85 (61%) required preoperative mechanical support (61%), and 55 did not (39%). Within the mechanical support group, 72 (85%) were ventilated, 44 (52%) received ECMO, and 31 (36%) had both ECMO and ventilation. Supported patients had higher LAS scores (89.3 vs 71.6, Conclusion: Preoperative mechanical support was associated with greater postoperative morbidity and worse long-term survival. These findings underscore the need to critically evaluate whether re-transplantation truly benefits this high-risk population.

Indexed as

graft failurelung re-transplantationmechanical supportprimary graft dysfunction

Identifiers

PMID42643254
PMCPMC13503123

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.