Evidence map›Paper›PMID 42643304›Full record

ArticleFrontiers in cellular and infection microbiology2026

Functional characterization of the IFN-γ protein in mediating antiviral defence against Newcastle disease Virus in

Hua Chang, Feiyan Dai, Honglin Cheng, Yi Chen, Xiaotong Zhao, Shengjie Ren, Hongli Zhang, Bofang Duan, Xun Xiang, Gang Duan

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Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hua Chang *College of Veterinary Medicine, Yunnan Agricultural University, Kunming, China.
Feiyan Dai *College of Veterinary Medicine, Yunnan Agricultural University, Kunming, China.
Honglin Cheng *College of Foreign Languages, Yunnan Agricultural University, Kunming, China.
Yi ChenCollege of Veterinary Medicine, Yunnan Agricultural University, Kunming, China.
Xiaotong ZhaoCollege of Animal Science and Technology, Yunnan Agricultural University, Kunming, China.
Shengjie RenCollege of Veterinary Medicine, Yunnan Agricultural University, Kunming, China.
Hongli ZhangCollege of Veterinary Medicine, Yunnan Agricultural University, Kunming, China.
Bofang DuanCollege of Veterinary Medicine, Yunnan Agricultural University, Kunming, China.
Xun XiangCollege of Veterinary Medicine, Yunnan Agricultural University, Kunming, China.
Gang DuanCollege of Veterinary Medicine, Yunnan Agricultural University, Kunming, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Newcastle disease virus (NDV) can spread across regions via migratory wild birds, posing potential threats to livestock breeding and public health security. Systematic information on the genetic characteristics, immunoregulatory functions, and antiviral activity of IFN-γ in the migratory wild bird Methods: In this study, the complete coding sequence of Results: NDV infection was associated with increased transcription of TLR7 pathway-related genes. Among the tested IFN-γ concentrations, 200 ng/mL produced the strongest TLR7 transcriptional response. IFN-γ intervention significantly reduced intracellular NDV NP transcript abundance, and this reduction coincided with lower transcription of TLR7 pathway-related genes under combined treatment. Discussion: These findings indicate that

Indexed as

Interferon-gammaNewcastle DiseaseNewcastle disease virusAnimalsCloning, MolecularGene Expression ProfilingLymphocytesReal-Time Polymerase Chain ReactionRecombinant ProteinsInterferon-gammaRecombinant Proteinsantiviral defenceIFN-γLarus ridibundusmigratory wildNewcastle disease virus

Identifiers

PMID42643304
PMCPMC13503165

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.