Knotted folds induced by homochiral all-parallel (or all-antiparallel) double-helices.

Stephen T Hyde, Myfanwy E Evans, Callum A R Metzke, Neave Taylor

Abstract read

In one paragraph

Article in PNAS nexus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Stephen T HydeSchool of Chemistry, University of Sydney, Camperdown, NSW 2006, Australia.ORCID https://orcid.org/0000-0003-2003-9992

Myfanwy E EvansInstitute for Mathematics, University of Potsdam, Potsdam, Germany.ORCID https://orcid.org/0000-0002-0161-6523

Callum A R MetzkeSchool of Mathematics and Statistics, University of Sydney, Sydney, NSW 2006, Australia.

Neave TaylorSchool of Chemistry, University of Sydney, Camperdown, NSW 2006, Australia.ORCID https://orcid.org/0009-0002-2290-9322

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many biomolecules and their synthetic counterparts preferentially assemble into double-helices with a preferred handedness and parallelism, such as all-antiparallel, right-handed double-helical polymorphs of DNA and RNA favored under ambient conditions by Watson-Crick duplexing. We analyze knots formed by double-helices which are exclusively all-parallel (or exclusively all-antiparallel) and all right-handed (or all left-handed) . Most simpler knot enantiomers are unrealizable. Among the nearly 500 distinct knot enantiomers with up to 10 crossings, fewer than 10% can be formed by such double-helices. Simplest designs for the folding of admissible knot enantiomers via duplexing of complementary base pairs in single-stranded RNA (or DNA) are enumerated for those knots.

Indexed as

double-helical assembliesduplexing of RNAknots

Identifiers

PMID42643843

DOI10.1093/pnasnexus/pgag278

PMCPMC13505510

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.