Evidence map›Paper›PMID 42644376›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2026

Disentangling MRI-derived blood-brain barrier leakage into vascular permeability and surface area.

Damon Verstappen, Joost Ja de Jong, Paulien Hm Voorter, Maud van Dinther, Robert J van Oostenbrugge, Julie Staals, Jacobus Fa Jansen, Walter H Backes

Abstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Damon VerstappenDepartment of Radiology & Nuclear Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands.ORCID 0000-0003-2329-5203
Joost Ja de JongDepartment of Radiology & Nuclear Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands.ORCID 0000-0003-4469-0763
Paulien Hm VoorterDepartment of Radiology & Nuclear Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands.ORCID 0000-0002-2724-4502
Maud van DintherDepartment of Neurology, Maastricht University Medical Centre+, Maastricht, The Netherlands.ORCID 0000-0001-7349-4783
Robert J van OostenbruggeMental Health and Neuroscience Research Institute (MHeNs), Maastricht University, Maastricht, The Netherlands.ORCID 0000-0003-1032-9099
Julie StaalsDepartment of Neurology, Maastricht University Medical Centre+, Maastricht, The Netherlands.ORCID 0000-0002-9502-6937
Jacobus Fa JansenDepartment of Radiology & Nuclear Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands.ORCID 0000-0002-5271-8060
Walter H BackesDepartment of Radiology & Nuclear Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands.ORCID 0000-0001-7905-0681

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In neurovascular and neurodegenerative diseases, blood-brain barrier (BBB) disruption can be subtle and diffuse, and MRI-derived measures are confounded by microvascular architecture. Therefore, we aimed to disentangle the MRI-derived blood-brain barrier leakage rate (

Indexed as

Blood–brain barriercerebral small vessel diseasedynamic contrast-enhanced MRIpermeabilitysurface area

Identifiers

PMID42644376
PMCPMC13586075

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.