Observational studyMediators of inflammation2026
Elevated C-Reactive Protein-Albumin-Lymphocyte Index Is Associated With Reduced Mortality in Chronic Inflammatory Airway Diseases: A Population-Based Observational Study.
Observational study in Mediators of inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Elevated C-Reactive Protein-Albumin-Lymphocyte Index Is Associated With Reduced Mortality in Chronic Inflammatory Airway Diseases: A Population-Based Observational Study.Mediators of inflammation · 2026Observational
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundThe C-reactive protein-albumin-lymphocyte (CALLY) index, a novel composite marker derived from lymphocyte count, serum albumin, and C-reactive protein (CRP) levels, is commonly used to assess nutritional and inflammatory status. However, existing studies have not clarified the association between the CALLY index and prognosis in patients with chronic inflammatory airway diseases (CIADs). This study aims to elucidate the relationship between the CALLY index and the risks of all-cause and cardiovascular mortality among CIAD patients in the United States.
methodsThis investigation included 4128 patients with CIAD from the National Health and Nutrition Examination Survey (NHANES, 1999-2010). The CALLY index was measured only at baseline. We employed weighted Cox proportional hazards regression models to assess the association between the CALLY index and risks of all-cause and cardiovascular mortality across three progressively adjusted models. To evaluate potential nonlinear dose-response relationships, we applied restricted cubic spline (RCS) models. Additionally, subgroup analyses and sensitivity analyses were conducted to verify the robustness of our findings.
resultsMultivariable-adjusted Model 3 demonstrated that, compared with the lowest quartile, the highest CALLY index quartile showed a significant inverse association with both all-cause and cardiovascular mortality, with corresponding HRs of 0.36 (95% CI: 0.27-0.47) and 0.33 (95% CI: 0.21-0.51), respectively (both p < 0.05).
conclusionsThe CALLY index showed a significant inverse association with all-cause and cardiovascular mortality among U.S. adults with CIAD, suggesting its potential value as a prognostic tool for risk stratification in this group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.