ArticleChemistry & biodiversity2026
Gallic Acid-Rich Ephedra alata: Integrated Phytochemical Profiling, Aromatase Docking, and Optimized Extraction via Box-Behnken Design.
Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study investigated the phenolic composition and antioxidant potential of E. alata using an integrated approach combining phytochemical profiling, molecular docking, and Box-Behnken optimization of extraction conditions. Stem extracts were prepared by maceration, sonication, and ultrasound-assisted extraction using dichloromethane, acetone, ethyl acetate, methanol, and methanol/water. Solvent polarity markedly affected extraction efficiency, with methanol and aqueous methanol yielding the highest extraction rates (up to 26.11 ± 0.01%), total phenolics (58.09 ± 1.07 mg GAE/g DW), flavonoids (9.81 ± 0.11 mg CE/g DW), condensed tannins (635.23 ± 3.05 mg CE/g DW), antioxidant capacity (500.46 ± 55.10 mg AAE/g DW), and the lowest DPPH IC
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