ReviewGels (Basel, Switzerland)2026
Mechanically Active Contractile Hydrogels for Skin Wound Repair.
Review in Gels (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Polymer hydrogels have been widely explored for wound repair, yet conventional designs remain passive barriers with limited mechanical intervention. Contractile hydrogels address this gap by undergoing network densification and macroscopic shrinkage, which can be converted into wound-edge traction through interfacial adhesion. This review classifies contractile hydrogels into temperature-responsive, pH-regulated, intermolecular-interaction-driven, and solvent-mediated systems according to their dominant contraction mechanisms. The transduction of contraction-derived mechanical cues into biochemical signals is discussed across tissue, cellular, and molecular scales, with emphasis on the well-supported integrin/focal adhesion kinase (FAK)-associated focal adhesion pathway and mechanosensitive ion channels. Current applications in acute full-thickness defects, infected and diabetic chronic wounds, surgical incisions, and scar control are critically surveyed. Finally, key challenges pertaining to force transmission efficiency, spatiotemporal controllability, biosafety, and clinical translatability are discussed. This review aims to provide design guidelines for the rational development of contractile hydrogel platforms for advanced wound management.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.