Evidence map›Paper›PMID 42645192›Full record

ArticleCells2026

Opioid Exposure Induces the Expression of the Purinergic Receptor

Jenna B Demeter, Sean D McNally, Maddy R Koch, Sherwin Thiyagarajan, Jeanette A Montoya, Liliana Vega, Paul Abboud, Sascha R A Alles, Reza Ehsanian, June Bryan I de la Peña

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jenna B DemeterTranslational Pain Group, Department of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.ORCID 0000-0001-5831-9442
Sean D McNallyTranslational Pain Group, Department of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Maddy R KochTranslational Pain Group, Department of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Sherwin ThiyagarajanTranslational Pain Group, Department of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.ORCID 0009-0003-9770-4628
Jeanette A MontoyaTranslational Pain Group, Department of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Liliana VegaTranslational Pain Group, Department of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Paul AbboudTranslational Pain Group, Department of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.ORCID 0009-0000-0990-5779
Sascha R A AllesDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0001-8532-8950
Reza EhsanianTranslational Pain Group, Department of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
June Bryan I de la PeñaTranslational Pain Group, Department of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.ORCID 0000-0001-9391-7595

Funding

Unfolded Protein Response and Autophagy in T Helper Cell Effector FunctionP20GM121176 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI VOJO P DERETIC · 2017 to 2026
$24.9M
NIGMS NIH HHS P20 GM121176NIH HHS 5P20GM121176-09
6 · The paper itself

Abstract

Primary sensory neurons of the dorsal root ganglion (DRG) express mu-type opioid receptors and undergo plasticity that can contribute to both analgesia and maladaptive outcomes such as opioid tolerance and opioid-induced hyperalgesia. Most mechanistic work has relied on rodent models, which may not fully capture the repertoire of opioid-responsive pathways present in humans. In this study, we tested whether morphine exposure reshapes gene expression programs in human nociceptors. Human induced pluripotent stem cell (hiPSC)-derived nociceptors were exposed to morphine (3.5 μM) acutely (1h, 16h) or repeatedly (2-3 days; daily 16h exposure separated by 8h washout) and profiled by time-series RNA sequencing. The transcriptional response to morphine included the induction of a small set of genes across exposure paradigms.

Indexed as

Analgesics, OpioidNociceptorsReceptors, Purinergic P2AnimalsGanglia, SpinalGene Expression RegulationHumansInduced Pluripotent Stem CellsMorphineSignal TransductionAnalgesics, OpioidMorphineP2RY11 protein, humanReceptors, Purinergic P2clustering analysishDRGlongitudinal RNA-seqmetabotropic purinoceptorP2Ypain

Identifiers

PMID42645192
PMCPMC13511635

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.