Evidence map›Paper›PMID 42645196›Full record

ArticleCells2026

Muscle-Derived Small Extracellular Vesicles Regulate Bone Maintenance During Hibernation Through miRNA-Mediated Signaling.

Yue He, Fangyang Pan, Yong Kong, Ziyi Zhang, Anni Wang, Mu Cui, Yuhong Niu, Yuan Gao, Kai Dang, Yongai Zhang

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yue HeSchool of Nursing and Rehabilitation, Xi'an Medical University, Xi'an 710021, China.ORCID 0000-0001-6859-8270
Fangyang PanKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an 710069, China.
Yong KongKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an 710069, China.
Ziyi ZhangResearch Center for Special Medicine and Health Systems Engineering, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710129, China.
Anni WangResearch Center for Special Medicine and Health Systems Engineering, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710129, China.
Mu CuiSchool of Nursing and Rehabilitation, Xi'an Medical University, Xi'an 710021, China.
Yuhong NiuSchool of Nursing and Rehabilitation, Xi'an Medical University, Xi'an 710021, China.
Yuan GaoResearch Center for Special Medicine and Health Systems Engineering, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710129, China.
Kai DangResearch Center for Special Medicine and Health Systems Engineering, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710129, China.
Yongai ZhangSchool of Nursing and Rehabilitation, Xi'an Medical University, Xi'an 710021, China.

Funding

Education Department of Shaanxi Province 25JC090National Natural Science Foundation of China 32070442National Natural Science Foundation of China 32071517
6 · The paper itself

Abstract

Prolonged skeletal muscle disuse, such as extended inactivity and mechanical unloading, typically elicits severe muscle atrophy and progressive bone loss, yet hibernating mammals evade this pathological cascade via poorly defined adaptive mechanisms. Using the Daurian ground squirrel (

Indexed as

Bone and BonesExtracellular VesiclesHibernationMicroRNAsMuscle, SkeletalSignal TransductionAnimalsCell DifferentiationMaleMiceOsteoblastsOsteogenesisSciuridaeMicroRNAshibernationmicroRNAmuscle–bone interactionsmall extracellular vesicles

Identifiers

PMID42645196
PMCPMC13511335

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.