Evidence map›Paper›PMID 42645202›Full record

ArticleCells2026

FHL3 Regulates Vascular Smooth Muscle Cell Phenotypic Switching Through the MRTFB-SRF Signaling Axis.

Xiaoxin Huang, Heming Zhang, Yanhong Zhang, Charles U Solomon, David G McVey, Shu Ye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaoxin HuangDivision of Basic Medicine, Shantou University Medical College, Shantou 515041, China.ORCID 0009-0003-0402-3613
Heming ZhangCardiovascular-Metabolic Disease Translational Research Programme, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.ORCID 0009-0005-7451-6610
Yanhong ZhangDivision of Basic Medicine, Shantou University Medical College, Shantou 515041, China.
Charles U SolomonDivision of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK.
David G McVeyDivision of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK.ORCID 0000-0002-6402-2546
Shu YeDivision of Basic Medicine, Shantou University Medical College, Shantou 515041, China.ORCID 0000-0002-4126-4278

Funding

National Medical Research Council MOH-001229National Medical Research Council MOH-001479
6 · The paper itself

Abstract

Genome-wide association studies have uncovered many coronary artery disease (CAD) loci, but mechanisms linking risk variants to vascular biology remain unclear. We screen candidate causal CAD genes for regulators of the vascular smooth muscle cell (VSMC) contractile phenotype using a pooled CRISPR-Cas9 knockout library in primary human VSMCs with MYH11 protein levels as the readout. FHL3 (four-and-a-half LIM domains protein 3) emerges as the top repressor of the contractile state. Colocalization analyses in a VSMC biobank and vascular tissues associate a CAD risk allele with reduced

Indexed as

Intracellular Signaling Peptides and ProteinsLIM Domain ProteinsMuscle ProteinsMuscle, Smooth, VascularMyocytes, Smooth MuscleSerum Response FactorSignal TransductionTrans-ActivatorsCell MovementCell ProliferationCoronary Artery DiseaseHumansMyosin Heavy ChainsPhenotypeTranscription FactorsFHL3 protein, humanIntracellular Signaling Peptides and ProteinsLIM Domain ProteinsMRTFB protein, humanMuscle ProteinsMyosin Heavy ChainsSerum Response FactorSRF protein, humanTrans-ActivatorsTranscription Factorscausal genecoronary artery diseaseFHL3MYH11VSMC

Identifiers

PMID42645202
PMCPMC13510585

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.