Evidence map›Paper›PMID 42645530›Full record

ArticlePsychopharmacology2026

Effects of withdrawal from intermittent vs. long access cocaine self-administration on nucleus accumbens calcium permeable AMPA receptor transmission and incubation of craving in female and male rats.

Amanda M Catalfio, Tracy L Fetterly, Megan Wickens, Terry E Robinson, Carrie R Ferrario

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Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Amanda M CatalfioDepartment of Pharmacology, University of Michigan, Ann Arbor, MI, 48109, USA.
Tracy L FetterlyDepartment of Pharmacology, University of Michigan, Ann Arbor, MI, 48109, USA.
Megan WickensDepartment of Pharmacology, University of Michigan, Ann Arbor, MI, 48109, USA.
Terry E RobinsonDepartment of Psychology (Brain and Behavior Area, University of Michigan, Ann Arbor, MI, 48109, USA.
Carrie R FerrarioDepartment of Pharmacology, University of Michigan, Ann Arbor, MI, 48109, USA. ferrario@umich.edu.

Funding

NIDA Training Program in Neuroscience-Administrative SupplementT32DA007281 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Shelly Beth Flagel · 1995 to 2026
$5.7M
Animal Models of AddictionR01DA044204 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FERRARIO, CARRIE · 2019 to 2023
$2.4M
CTSA Postdoctoral T32 at the University of MichiganT32TR004764 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VICKI L ELLINGROD, Steven Edward Harte · 2024 to 2026
$1.4M
NCATS NIH HHS T32TR004764NIDA NIH HHS R01DA044204NIDA NIH HHS T32DA007281
6 · The paper itself

Abstract

rationaleFollowing the discontinuation of long access (LgA) to cocaine self-administration rats show a time-dependent increase in motivation for drug ("incubation of craving") thought to be mediated by enhancements in transmission via nucleus accumbens (NAc) calcium-permeable AMPA receptors (CP-AMPARs). Intermittent access (IntA) to cocaine produces even more robust addiction-like behavior than LgA, but it is not known if this produces comparable incubation of craving and effects on CP-AMPARs.

methodsRats underwent 5 days of short access training followed by 10 days of LgA or IntA cocaine self-administration; drug naïve rats served as controls. Some rats were used for within-subject incubation testing at withdrawal days 1, 30 and 45, while others were used to measure the effects of LgA and IntA experience on CP-AMPAR-mediated transmission at withdrawal day 30-35.

resultsIntA and LgA self-administration followed by withdrawal resulted in similar patterns of incubation across both sexes. Additionally, CP-AMPAR-mediated transmission was similarly enhanced in LgA and IntA groups compared to drug naïve animals.

conclusionsDespite much less total cocaine consumption IntA resulted in incubation of craving and enhancements in NAc CP-AMPAR plasticity similar to LgA. This adds to a growing literature demonstrating that the intermittency of cocaine consumption can produce robust neurobehavioral plasticity comparable to LgA, in the absence of high levels of cocaine consumption.

Indexed as

AMPA receptorsEscalationGlutamatergic plasticityIncubationIntravenous self-administrationSex differencesStriatum

Identifiers

PMID42645530

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.