ReviewJournal of neurovirology2026
Chandipura virus encephalitis: an emerging pediatric neurotropic threat in india-virology, epidemiology, pathogenesis, and public health challenges.
Review in Journal of neurovirology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chandipura virus (CHPV) is an emerging neurotropic RNA virus and member of the Rhabdoviridae family, causing outbreaks of acute encephalitis in India, mostly in children under 15 years of age. The manuscript reviews in detail the virology, genetics, clinical features, epidemiology, transmission, immunopathogenesis, and treatment of CHPV. CHPV rapidly infects neuronal tissue and activates the extrinsic pathways of neuronal apoptosis through Fas-mediated apoptosis, resulting in rapid neuronal degeneration within 24-48 h. The recent re-emergence of CHPV is another significant re-emergence in Gujarat in 2024, with the distribution of cases by space and time further suggesting CHPV is seasonal, adds new districts, and is still a threat to children. Outbreaks of CHPV typically coincide with monsoonal flooding, and Phlebotomus sandflies primarily spread the disease. The monsoonal flooding and environmental degradation that occurred during the breeding season, rendering sandflies more susceptible to outbreaks, are remarkable. Differentiation of other encephalitic viruses, such as Japanese encephalitis, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and dengue, is important for clinical diagnosis and also because of the rapid progression of CHPV. Several points to consider are low CSF pleocytosis and the neuroimaging characteristics that are identifiable. The immune response after infection is marked by a cytokine storm, followed by lymphocyte apoptosis and reduction in CNS viral clearance. Over the past decade, laboratories in India have developed in the realm of diagnosis and treatment of CHPV with the advent of molecular diagnostics such as real-time RT-PCR and IgM ELISA. However, a lack of a licensed vaccine and antivirals would make this new infectious disease more difficult to manage. This review highlights the critical importance of further surveillance, vector control, public health preparedness, and vaccine development/therapeutics for CHPV.
Indexed as
Identifiers
42645624What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.