ArticleInflammopharmacology2026
In vivo and in vitro investigation of skin anti-inflammatory effect of Sumac (Rhus coriaria L.).
Article in Inflammopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSumac (Rhus coriaria L., Anacardiaceae) fruit is receiving a growing attention as potential nutraceutical and cosmetic ingredient. It is appreciated either as a spice and medicinal remedy in Middle East countries. The application of fruits preparations to skin injuries emerged from ethnopharmacological studies, sustained by few experimental studies on wound healing. The present work, based on previous evidence of in vitro anti-inflammatory activity in human keratinocytes (HaCaT), is aimed at translating the in vitro effect of sumac to an in vivo model of dermatitis.
resultsTwo polar sumac fruit extracts (acetone extract, ARC; ethanol extracts, mERC) were investigated in mice by Croton oil-induced ear dermatitis model. The in vivo topical anti-inflammatory activity was investigated 6 h and 24 h after dermatitis induction by means of edema, leukocyte infiltrate, and histological features; the expression of inflammatory genes was also analyzed by PCR array. Biological targets identified in vivo were validated in vitro by stimulating HaCaT cells with pro-inflammatory mediators for the same exposure time-points (6 h and 24 h). Both the extracts inhibited PMA-induced IL8 release in HaCaT cells, but mERC showed lower IC
conclusionsThis study supports the relevance of the biological properties of sumac fruit for skin inflammation. Moreover, mechanisms of action related to TNF and IL4/IL13 pathways suggest further specific investigations related to skin allergy and autoimmune diseases.
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