ArticleJournal of cardiovascular development and disease2026
Association of Composite Metabolic, Inflammatory, and Nutritional Indices with Right Ventricular Dysfunction in Acute Pulmonary Embolism: A Retrospective Cohort Study.
Article in Journal of cardiovascular development and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesRight ventricular dysfunction (RVD) is a major determinant of adverse outcomes in patients with acute pulmonary embolism (PE). Several laboratory-derived composite indices reflecting metabolic, inflammatory, thrombotic, and nutritional status have been proposed as prognostic markers in cardiovascular diseases; however, their relationship with imaging-defined RVD in acute PE remains insufficiently investigated. This study aimed to evaluate the association between metabolic, inflammatory, thrombotic, and nutritional indices and RVD in patients with acute PE.
methodsThis retrospective observational cohort study included 270 patients with acute PE treated at a tertiary referral center between January 2024 and March 2026. Patients were categorized according to the presence or absence of RVD determined by echocardiographic and/or computed tomography pulmonary angiography criteria. The triglyceride-glucose (TyG) index, triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-C), blood urea nitrogen-to-albumin ratio (BAR), C-reactive protein-to-albumin ratio (CAR), lactate-to-albumin ratio (LAR), D-dimer-to-albumin ratio (DAR), fibrinogen-to-albumin ratio (FAR), and prognostic nutritional index (PNI) were calculated from admission laboratory data. Logistic regression, receiver operating characteristic (ROC), DeLong, and correlation analyses were performed.
resultsAmong the 270 patients, 118 (43.7%) had RVD and 152 (56.3%) did not. Patients with RVD demonstrated significantly higher thromboembolic burden, more severe imaging findings, and worse clinical outcomes. All investigated composite indices differed significantly between groups (all
conclusionsSeveral metabolic, inflammatory, thrombotic, and nutritional indices were associated with imaging-defined RVD in acute PE. DAR yielded the numerically highest AUC and the strongest correlations among the composite indices but was not statistically superior to CAR, PNI, or LAR. These exploratory findings do not establish incremental value beyond D-dimer, cardiac biomarkers, established risk scores, or imaging.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.