ArticleJournal of fungi (Basel, Switzerland)2026
The Diagnostic Challenge in Pulmonary Cryptococcosis Among Immunocompetent Patients: The 'False-Negative' Serum Cryptococcal Antigen.
Article in Journal of fungi (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
Funding
Abstract
objectiveTo delineate the demographic, clinical, and radiological features of immunocompetent patients with pulmonary cryptococcosis (PC) who test negative for serum cryptococcal antigen (CrAg), a subgroup that poses a diagnostic challenge.
methodsParticipants were stratified into CrAg-positive (
resultsPatients with false-negative CrAg results were more likely to be asymptomatic (46.5% vs. 20.3% in the CrAg-positive group;
conclusionsFalse-negative serum CrAg in immunocompetent PC patients is characterized by an asymptomatic presentation and a solitary nodule on imaging, with normal laboratory parameters. CrAg titers may reflect disease severity and warrant prospective evaluation as a potential biomarker for guiding antifungal therapy.
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