ArticleJournal of veterinary internal medicine2026
High molecular weight adiponectin as an adjunct biomarker for insulin dysregulation in equids.
Article in Journal of veterinary internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
Funding
Abstract
backgroundTotal adiponectin concentration is associated with hyperinsulinemia and laminitis risk in ponies but the high molecular weight (HMW) multimer is a more sensitive indicator of metabolic disease in other species and could be a useful biomarker for insulin dysregulation (ID). HYPOTHESIS/
objectivesTo determine a cut-off value for using HMW adiponectin as an adjunct diagnostic tool for ID. ANIMALS: Cohort of 127 privately and university-owned horses and ponies of various breeds with 55 classified as ID positive and 72 as ID negative.
methodsCohort study. Baseline and postprandial blood samples from an in-feed oral glucose test (0.75 g/kg dextrose) were used to determine ID status. Insulin and HMW adiponectin concentrations were measured using validated immunoassays. High molecular weight adiponectin cut-off values were derived with receiver-operator characteristic curve analysis using a bootstrap method to maximize the sum of sensitivity and specificity.
resultsMedian [IQR] HMW adiponectin concentration was higher (P < .001) in ID negative animals (4.19 [2-6.5] μg/mL) compared to ID positive animals (1.79 [0.63-3.5] μg/mL), with a cut-off value (95% CI) of 2.1 (1.26, 3.15) μg/mL (area under the curve 0.71; sensitivity 0.62; and specificity 0.74). Horses had higher (P < .001) HMW adiponectin concentrations (4.38 [2.22-7.3] μg/mL) than ponies (1.84 [0.64-3.75] μg/mL). However, HMW adiponectin did not differ between horses with and without ID, and both horse subgroups had concentrations higher (P ≤ .002) than ponies with ID. CONCLUSIONS AND CLINICAL IMPORTANCE: Use of a single cut-off value for HMW adiponectin as an adjunct biomarker for ID for both horses and ponies is not accurate.
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