ArticleJournal of Parkinson's disease2026
Serotonin content and uptake in platelets can distinguish Parkinson's disease from control patients and essential tremor.
Article in Journal of Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We have demonstrated that platelets from Parkinson's disease patients exhibit impaired serotonin uptake and release. This seems to be caused by a dysfunction in secretory vesicles (SecVs), which share the mechanisms of accumulation with dopaminergic neurons. As a working hypothesis, this dysfunction may create an excess of dopamine causing neurotoxicity a process absent in other conditions like Essential Tremor or Essential Tremor Plus. The serotonin functional analysis in platelets is a potential tool to reduce misdiagnosis.To validate this, we performed a functional study using liquid chromatography (UHPLC) to analyze serotonin content, uptake, and secretion in platelets from 50 Parkinson's disease patients, 23 essential tremor, 17 essential tremor plus, and 50 controls.Parkinson's disease patients show impaired platelet serotonin content and uptake
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