ArticleAntioxidants (Basel, Switzerland)2026
Vitamin D Receptor Polymorphisms and Their Association with Nrf2-Dependent Gene Expression in Oxidative Stress Resilience in Cognitively Healthy Aging.
Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The vitamin D receptor (VDR) exerts pleiotropic effects essential for human health and modulates the transcription of nuclear factor erythroid 2-related factor 2 (Nrf2), a key regulator of the cellular antioxidant defense system. Polymorphisms represent a major source of interindividual variability and may influence susceptibility to oxidative stress. The VDR polymorphisms ApaI (A > C) and TaqI (T > C) have been associated with disease susceptibility; however, their role in oxidative stress responses during aging remains poorly understood. This study evaluated the association between ApaI and TaqI polymorphisms and susceptibility to oxidative stress-induced cell death, as well as the expression of genes within the VDR-Nrf2 signaling axis, in peripheral blood mononuclear cells (PBMCs) from cognitively healthy Chilean older adults. VDR genotyping was performed using real-time PCR (TaqMan SNP Genotyping Assay), PBMC viability following H
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