Downregulation of the L-PGDS/15d-PGJ2 Pathway Is Associated with Manganese-Induced Neuroinflammation and Cognitive Impairment Involving C/EBPβ and MMP9.

Junrou Zhang, Kai Xu, Yan Ye, Junxiang Ma, Li Chen, Tian Chen, Piye Niu

Abstract read

In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Junrou ZhangBeijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, Beijing 100069, China.

Kai XuBeijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, Beijing 100069, China.ORCID 0000-0002-2038-7156

Yan YeDepartment of Occupational Health, Beijing Center for Disease Control and Prevention, Beijing 100020, China.

Junxiang MaBeijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, Beijing 100069, China.

Li ChenBeijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, Beijing 100069, China.

Tian ChenBeijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, Beijing 100069, China.

Piye NiuBeijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, Beijing 100069, China.ORCID 0000-0002-0155-3438

Funding

National Natural Science Foundation of China 81973007

6 · The paper itself

Abstract

Excessive manganese (Mn) exposure is associated with neuroinflammation and cognitive impairment, yet the contribution of endogenous pro-resolving pathways to Mn neurotoxicity remains incompletely understood. Here, we examined the involvement of the lipocalin-type prostaglandin D synthase (L-PGDS)/15-deoxy-Δ

Indexed as

15d-PGJ2cognitive functioninflammationmanganese

Identifiers

PMID42650221

DOI10.3390/antiox15080957

PMCPMC13510188

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.