Evidence map›Paper›PMID 42650242›Full record

ArticleAntioxidants (Basel, Switzerland)2026

Sexual Dimorphism in Placental mTORC1 Signaling, Amino Acid Transport, and Mitochondrial Respiration at Term.

Hiroshi Shimada, Toshihide Sakuragi, Vincent Zaegel, Anita Kramer, Kristen E Boyle, Theresa L Powell, Thomas Jansson, Fredrick J Rosario

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hiroshi ShimadaDepartment of Obstetrics and Gynecology, University of Colorado Anschutz, Aurora, CO 80045, USA.ORCID 0000-0002-4049-6376
Toshihide SakuragiDepartment of Obstetrics and Gynecology, University of Colorado Anschutz, Aurora, CO 80045, USA.ORCID 0000-0003-1724-6755
Vincent ZaegelDepartments of Pediatrics, Basic Science Research Core, LEAD Center, University of Colorado Anschutz, Aurora, CO 80045, USA.
Anita KramerDepartment of Obstetrics and Gynecology, University of Colorado Anschutz, Aurora, CO 80045, USA.
Kristen E BoyleDepartments of Pediatrics, Basic Science Research Core, LEAD Center, University of Colorado Anschutz, Aurora, CO 80045, USA.ORCID 0000-0001-9689-3322
Theresa L PowellDepartment of Obstetrics and Gynecology, University of Colorado Anschutz, Aurora, CO 80045, USA.
Thomas JanssonDepartment of Obstetrics and Gynecology, University of Colorado Anschutz, Aurora, CO 80045, USA.ORCID 0000-0002-8123-9480
Fredrick J RosarioDepartment of Obstetrics and Gynecology, University of Colorado Anschutz, Aurora, CO 80045, USA.ORCID 0000-0001-7282-7005

Funding

Trophoblast mTOR: a critical hub linking maternal nutrient supply to placental function, fetal growth and fetal islet functionR01HD068370 · NICHD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JANSSON, THOMAS, ROSARIO-JOSEPH, FREDRICK · 2011 to 2024
$4.1M
Development of approaches for inducible trophoblast-specific gene modulation: the role of trophoblast Lat1 in the regulation of placental function and fetal growthR01HD105701 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Thomas L Brown, Thomas Jansson · 2023 to 2026
$2.6M
NICHD NIH HHS R01 HD068370NICHD NIH HHS R01 HD105701NIH HHS 1R01HD105701-07
6 · The paper itself

Abstract

Male fetuses generally grow faster in utero and are heavier at birth than females, whereas the rates of perinatal mortality and morbidity are often higher in boys than in girls. Sexual dimorphism in placental function is believed to contribute to these differences. However, evidence for sex-specific differences in placental function remains limited. We hypothesized that placental nutrient-sensing signaling activity, amino acid transport capacity, and mitochondrial respiration are higher in male than female placentas. Placentas were collected from 46 women (BMI 18.5-29.9 kg/m

Indexed as

fetal growthhumanmaternal–fetal exchangemitochondrial functionnutrient transport

Identifiers

PMID42650242
PMCPMC13509233

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.