Evidence map›Paper›PMID 42650282›Full record

ArticleAntioxidants (Basel, Switzerland)2026

Sustainable Ellagitannin-Rich Pomegranate Peel Extracts Activate SKN-1/NRF2-Dependent Antioxidant Responses and Promote Healthy Aging in

Emily Schifano, Francesco Cairone, Marco Guarnieri, Andrea Bonfanti, Patrizia Mancini, Irene Arpante, Arianna Montanari, Cristina Mazzoni, Daniela Uccelletti, Stefania Cesa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emily SchifanoDepartment for Well-Being, Health and Environmental Sustainability-BeSSA, Sapienza University of Rome, Via della Fontanelle, 02100 Rieti, Italy.
Francesco CaironeDepartment of Chemistry and Technologies of Drug, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0002-9618-1410
Marco GuarnieriDepartment of Biology and Biotechnologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0009-0003-1299-9288
Andrea BonfantiDepartment of Biology and Biotechnologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0009-0002-3515-5486
Patrizia ManciniDepartment of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.ORCID 0000-0003-0556-2056
Irene ArpanteDepartment of Chemistry and Technologies of Drug, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0009-0005-3994-7036
Arianna MontanariDepartment of Biology and Biotechnologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0001-6832-7569
Cristina MazzoniDepartment of Biology and Biotechnologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0002-1504-6189
Daniela UccellettiDepartment of Biology and Biotechnologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0001-6841-8129
Stefania CesaDepartment of Chemistry and Technologies of Drug, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0002-8649-0017

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The valorization of food by-products represents a key strategy for sustainable food systems and the circular bioeconomy. Pomegranate peels from two selected Italian cultivars were subjected to environmentally friendly extraction processes aimed at optimizing ellagitannins' recovery and exploiting their biological activity. Punicalagin (PU) was the predominant compound, and the extracts exhibited high antioxidant capacity in both DPPH and FRAP assays. The Granato cultivar was selected for in vivo evaluation on the

Indexed as

antioxidant activityCaenorhabditis elegansellagitanninsoxidative stresspomegranate peelSKN-1/NRF2

Identifiers

PMID42650282
PMCPMC13509578

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.