ArticleAntibiotics (Basel, Switzerland)2026
Towards Antimicrobial Formulations of Repurposed Drugs and Cationic Surfactants: Efficacy, Cytotoxicity on Human Cell Lines, and Ecotoxicity in Aquatic Models.
Article in Antibiotics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
8 authors.
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Abstract
backgroundAntimicrobial combination therapies outperform traditional monotherapies by offering additive or synergetic effects, a broader spectrum of activity, enhanced efficacy against polymicrobial infections, and a reduced risk of resistance development and infection relapse.
methodsHerein, we have combined the chemotherapeutic antibiotic alkylating agent mitomycin C (MMC) with the wide-spectrum antiseptic octenidine hydrochloride (OCT). The non-specific mode of action via membrane disruption of the latter, together with the DNA-alkylating ability of the former, is here combined to produce bactericidal antibiotic-like mixtures against clinical isolates of Methicillin-resistant
resultsCompared to monotherapy, these environmentally friendly antibiotic-like combinations at specific concentrations may achieve additive antimicrobial effects against planktonic, sessile, and intracellular pathogenic strains. However, the ecotoxicological response was bioindicator-dependent: the OCT-MMC combination reduced toxicity in
conclusionsCollectively, these findings demonstrate that selected MMC-OCT combinations achieve antibacterial efficacy against planktonic, sessile, and intracellular pathogenic bacteria while preserving the viability of eukaryotic cells and exhibiting minimal toxicity toward standard ecotoxicological model organisms. Further studies are needed to guarantee the safe use of this combination at selected doses and to guarantee its non-systemic absorption after topical administration.
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