IFNλ4 Gene Variants Are Associated with CD8

Giuseppa Luisa Sanfilippo, Giusto Davide Badami, Marco Pio La Manna, Mariangela Pizzo, Domenico Lio, Giovanni Maurizio Giammanco, Nadia Caccamo

Abstract read

PubMed Full text at PMC Publisher

In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giuseppa Luisa SanfilippoG. Giglio Institute Foundation, 90015 Cefalù, Italy.

Giusto Davide BadamiCentral Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), Azienda Ospedaliera Universitaria Policlinico (AOUP) Paolo Giaccone, University of Palermo, 90127 Palermo, Italy.ORCID 0000-0003-0395-9789

Marco Pio La MannaCentral Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), Azienda Ospedaliera Universitaria Policlinico (AOUP) Paolo Giaccone, University of Palermo, 90127 Palermo, Italy.ORCID 0000-0002-3327-9541

Mariangela PizzoMicrobiology, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy.

Domenico LioUniversity Research Center "Migrate", University of Palermo, 90133 Palermo, Italy.ORCID 0000-0003-4550-1389

Giovanni Maurizio GiammancoMicrobiology, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy.ORCID 0000-0002-7874-6289

Nadia CaccamoCentral Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), Azienda Ospedaliera Universitaria Policlinico (AOUP) Paolo Giaccone, University of Palermo, 90127 Palermo, Italy.ORCID 0000-0002-1018-5710

Funding

University of Palermo FFR2025University of Palermo FFR2026

6 · The paper itself

Abstract

Individual responses to SARS-CoV-2 vaccination vary due to viral mutations, demographic factors, and genetic background, with T-cell responses being less affected by viral variability. However, less is known about the effect of age, sex, and genetic background on the T-cell response in vaccinated subjects. In particular, the influence of interferon lambda (IFN-λ) genetic polymorphisms on vaccine-induced cellular immunity has been poorly explored. Here, we assessed intracellular production of IFNγ, TNFα, and IL-2 in CD4

Indexed as

CD8-Positive T-LymphocytesCOVID-19COVID-19 VaccinesInterleukin-2InterleukinsAdultCD4-Positive T-LymphocytesFemaleGenotypeHumansInterferon LambdaInterferonsMaleMiddle AgedPolymorphism, Single NucleotideSARS-CoV-2COVID-19 VaccinesIFNL4 protein, humanInterferon LambdaInterferonsInterleukin-2Interleukinscytokine productionIFN-lambdaSARS-CoV-2 vaccinesingle-nucleotide polymorphism (SNP)T-cell response

Identifiers

PMID42650779

DOI10.3390/biom16081111

PMCPMC13511631

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.