Evidence map›Paper›PMID 42650824›Full record

ArticleBiomolecules2026

Honokiol Suppresses Glioma Cell Proliferation by Disrupting SUMO1-YAP1 Conjugation and Promoting YAP1 Proteasomal Degradation.

Zenghua Sheng, Qiaoyun Fang, Siqian Cui, Jian Wang, Huihui Xiao, Chunrong Wu, Debing Xiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zenghua ShengDepartment of Oncology, Jiangjin Hospital, School of Medicine, Chongqing University, Chongqing 402260, China.ORCID 0000-0003-1834-3733
Qiaoyun FangDepartment of Oncology, Jiangjin Hospital, School of Medicine, Chongqing University, Chongqing 402260, China.
Siqian CuiDepartment of Oncology, Jiangjin Hospital, School of Medicine, Chongqing University, Chongqing 402260, China.
Jian WangDepartment of Oncology, Jiangjin Hospital, School of Medicine, Chongqing University, Chongqing 402260, China.
Huihui XiaoDepartment of Oncology, Jiangjin Hospital, School of Medicine, Chongqing University, Chongqing 402260, China.
Chunrong WuDepartment of Oncology, Jiangjin Hospital, School of Medicine, Chongqing University, Chongqing 402260, China.ORCID 0000-0002-8635-5106
Debing XiangDepartment of Oncology, Jiangjin Hospital, School of Medicine, Chongqing University, Chongqing 402260, China.ORCID 0009-0002-4258-2224

Funding

National Natural Science Foundation of China 82504052Natural Science Foundation of Chongqing CSTB2024NSCQ-KJFZZDX0042Natural Science Foundation of Chongqing CSTB2024NSCQ-MSX1239Scientific and Technological Research Program of Chongqing Municipal Education Commission KJQN202500114Scientific and Technological Research Program of Chongqing Municipal Education Commission KJZD-K202500101
6 · The paper itself

Abstract

Among primary central nervous system malignancies in adults, malignant glioma ranks first in incidence, with glioblastoma (GBM) standing as its most aggressive phenotype. This malignancy remains a devastating disease with limited therapeutic options, largely owing to the intricate network of dysregulated signaling pathways. SUMOylation, a post-translational modification that governs thousands of substrate proteins, is markedly hyperactivated in GBM and represents a rational but underexploited target. Here, we found that honokiol (HNK), a natural biphenolic compound extracted from the traditional Chinese medicine

Indexed as

Adaptor Proteins, Signal TransducingBiphenyl CompoundsGliomaLignansProteasome Endopeptidase ComplexSUMO-1 ProteinTranscription FactorsAllyl CompoundsCell Line, TumorCell ProliferationHumansPhenolsProteolysisSignal TransductionSumoylationYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingAllyl CompoundsBiphenyl CompoundshonokiolLignansPhenolsProteasome Endopeptidase ComplexSUMO-1 ProteinTranscription FactorsYAP1 protein, humanYAP-Signaling ProteinsGBMhonokiollabel-free proteomicsSUMOylationubiquitinationYAP1

Identifiers

PMID42650824
PMCPMC13511501

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.