Evidence map›Paper›PMID 42650865›Full record

ReviewBiomolecules2026

MicroRNAs: A Social Network in Diabetic Retinopathy.

Sheila Ngumbi, Mohamed S Gad, Kara Ye, Sarah Ye, Christie Taylor, Mostafa Mahrous, Manuela Bartoli

Abstract readReview
In one paragraph

Review in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sheila NgumbiDepartment of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Mohamed S GadDepartment of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-3473-7062
Kara YeDepartment of Ophthalmology, LSU Health, New Orleans, LA 70112, USA.ORCID 0000-0003-0253-0112
Sarah YeDepartment of Ophthalmology, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0001-9165-5966
Christie TaylorDepartment of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Mostafa MahrousDepartment of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-6185-8815
Manuela BartoliDepartment of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.

Funding

Module 3: Gene Expression/ProteomicsP30EY031631 · NEI · AUGUSTA UNIVERSITY · PI Xingjun Fan · 2020 to 2026
$3.6M
Inflammaging and Diabetic RetinopathyR01EY034684 · NEI · AUGUSTA UNIVERSITY · PI MANUELA BARTOLI · 2024 to 2026
$1.4M
National Institute of Health EY034684NEI NIH HHS P30 EY031631NEI NIH HHS P30EY031631NEI NIH HHS R01 EY034684
6 · The paper itself

Abstract

In recent years, the role of non-coding RNAs in human physiology and pathology has emerged as an essential avenue of investigation. Among others, studies identifying the biological role of microRNAs (miRNAs) have paved the way for future inquiries on the importance and biological significance of non-coding RNAs. In this review, we provide an overview of miRNAs' biology and their contribution to the pathogenesis of diabetic retinopathy (DR). This complication of diabetes is the leading cause of blindness in adults, affecting more than 4 million people in the US alone and over 103 million people worldwide. Despite the tremendous efforts of the scientific community and the pharmaceutical industry, the development of new, more effective therapeutic and diagnostic tools for DR to date remains an unmet need. More than a decade from the initial work assessing miRNA expression profiles in diabetic patients, we have learned the impact of these signaling molecules in DR and garnered knowledge of their complexity and their potential as new diagnostic and therapeutic targets for this potentially blinding condition.

Indexed as

Diabetic RetinopathyMicroRNAsAnimalsHumansMicroRNAsangiogenesisbiomarkersdiabetic retinopathyexosomesinflammationMicroRNAs (miRNAs)miRNA-based therapeuticsnon-coding RNAsoxidative stressretinal vascular dysfunction

Identifiers

PMID42650865
PMCPMC13510794

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.