Evidence map›Paper›PMID 42651660›Full record

ArticleBiology2026

Intermittent Administration Alleviates Enrofloxacin-Induced Hepatotoxicity in Zebrafish via Adaptive Lipid Remodeling and p38 MAPK Signaling.

Jiangkun Yu, Yiming Liu, Yake Gao, Dingxi Pan, Mingying Li, Wei Guo

Abstract read
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jiangkun YuState Key Laboratory of Conservation and Utilization of Bio-Resources, School of Life Sciences, Center for Life Sciences, Yunnan University, Kunming 650500, China.ORCID 0000-0002-1832-7832
Yiming LiuState Key Laboratory of Conservation and Utilization of Bio-Resources, School of Life Sciences, Center for Life Sciences, Yunnan University, Kunming 650500, China.
Yake GaoState Key Laboratory of Conservation and Utilization of Bio-Resources, School of Life Sciences, Center for Life Sciences, Yunnan University, Kunming 650500, China.
Dingxi PanSchool of Ecology and Environmental Science, Yunnan University, Kunming 650500, China.
Mingying LiState Key Laboratory of Conservation and Utilization of Bio-Resources, School of Life Sciences, Center for Life Sciences, Yunnan University, Kunming 650500, China.
Wei GuoState Key Laboratory of Conservation and Utilization of Bio-Resources, School of Life Sciences, Center for Life Sciences, Yunnan University, Kunming 650500, China.ORCID 0000-0002-9699-9319

Funding

Innovation Project of the Color Cloud Postdoctoral Program C615300504064National Natural Science Foundation of China 22306154NHC Key Laboratory of Prevention and Control of Birth Defects and Reproductive Health in Western China 2023XBYSKF004
6 · The paper itself

Abstract

Enrofloxacin (ENR) has been widely used in global aquaculture production, yet its hepatotoxic impacts under different operational administration modes remain poorly understood. Current environmental risk assessments and therapeutic guidelines generally assume that cumulative exposure dose dictates biological outcomes, largely ignoring the temporal patterns of drug administration. In the present study, we systematically compared the hepatotoxic, metabolic, and molecular effects of two matched-duration ENR administration regimens, continuous versus intermittent, on adult zebrafish (

Indexed as

administration regimenenrofloxacinlipid metabolismMAPKzebrafish

Identifiers

PMID42651660
PMCPMC13509458

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.